Results 41 to 50 of about 850,416 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dose–response relationship between transfusion and the incidence of infection in critically ill patients: a systematic review and dose–response meta-analysis

Journal of Intensive Care
Purpose To estimate the association between red blood cell (RBC) transfusion volume and hospital-acquired infections (HAI) in critically ill patients, with a particular focus on identifying the potential threshold volumes at which infection risk changes.
Shodai Yoshihiro, Yuki Kataoka, Takashi Hongo, Takahiro Tsuge, Hiroaki Matsuo   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Narrow-Band Imaging vs. Magnifying Chromoendoscopy for the Diagnosis of Early Colorectal Cancer Invasion Depth: Systematic Review and Meta-Analysis

Endoscopy International Open
Background and study aim: Optical assessment of deep submucosal invasion (T1b) in T1 colorectal cancer (CRC) is critical for selecting endoscopic versus surgical management.
Tomoyuki Nishimura, Kareem Khalaf, Yuki Kataoka, Jun Watanabe, Yuhong Yuan, Tommy Rizkala, Nana Hayashi, Natalia Casuada Calo, Gary May, Jeffrey D Mosko   +9 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Stability-Optimal Grouping Strategy of Peer-to-Peer Systems [PDF]

IEEE Transactions on Parallel and Distributed Systems, 2011
When applied in high-churn Internet environments, P2P systems face a dilemma: although most participants are too unstable, a P2P system requires sufficient stable peers to provide satisfactory core services. Thus, determining how to leverage unstable nodes seems to be the only choice.
Zhenhua Li 0001, Jie Wu 0001, Junfeng Xie, Tieying Zhang, Guihai Chen, Yafei Dai   +5 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Outside belonging: A study of bullying in a daycare institution

Nordisk Barnehageforskning, 2017
In this study of bullying during children’s play and other interactions in a daycare setting, the empirical data are based on interviews with staff and notes from discussions with staff and with two special education teachers.
Mai Brit Helgesen
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source