Results 41 to 50 of about 959,546 (306)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Population mortality before and during the COVID-19 epidemic in two Sudanese settings: a key informant study

BMC Public Health
Background Population mortality is an important metric that sums information from different public health risk factors into a single indicator of health.
Rahaf AbuKoura, Francesco Checchi, Omama Abdalla, Omnia Ibrahim, Ahmed Tom Hemeadan, Ahmed Ali Ahmed Eldirdiri, Direeg Ismail Mohamed, Aljaile Ahmed, Abd Elhameed Ahmed, Nada Abdelmagid, Pasquale Pepe, Maysoon Dahab   +11 more
doaj   +1 more source

Establishing a peer advisory board in a mental health ethics research group – challenges, benefits, facilitators and lessons learned

Frontiers in Psychiatry
While participatory methods are regarded as beneficial in many areas of psychiatric research, they are still rarely considered in the field of mental health ethics.
Mirjam Faissner, Mirjam Faissner, Esther Braun, Esther Braun, Simone Agnes Efkemann, Anne-Sophie Gaillard, Iris Haferkemper, Christin Hempeler, Imke Heuer, Ursula Lux, Sarah Potthoff, Sarah Potthoff, Matthé Scholten, Sylvia Spiegel, Christina Stefaniak, Madeleine Thesing, Anna Werning, Jakov Gather, Jakov Gather   +18 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Stability-Optimal Grouping Strategy of Peer-to-Peer Systems [PDF]

IEEE Transactions on Parallel and Distributed Systems, 2011
When applied in high-churn Internet environments, P2P systems face a dilemma: although most participants are too unstable, a P2P system requires sufficient stable peers to provide satisfactory core services. Thus, determining how to leverage unstable nodes seems to be the only choice.
Zhenhua Li 0001, Jie Wu 0001, Junfeng Xie, Tieying Zhang, Guihai Chen, Yafei Dai   +5 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Group Formation Among Peer-to-Peer Agents: Learning Group Characteristics [PDF]

, 2004
This paper examines the decentralized formation of groups within a peer-to-peer multi-agent system. More specifically, it frames group formation as a clustering problem, and examines how to determine cluster characteristics such as area and density in the absence of information about the entire data set, such as the number of points, the number of ...
Elth Ogston, Benno J. Overeinder, Maarten van Steen, Frances M. T. Brazier   +3 more
openaire   +2 more sources

Maintaining unlinkability in group based P2P environments [PDF]

, 2009
In the wake of the success of Peer-to-Peer (P2P) networking, security has arisen as one of its main concerns, becoming a key issue when evaluating a P2P system.
Joan Arnedo-Moreno, Arnedo Moreno, Joan, Jordi Herrera-Joancomarti, Herrera Joancomartí, Jordi   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dose–response relationship between transfusion and the incidence of infection in critically ill patients: a systematic review and dose–response meta-analysis

Journal of Intensive Care
Purpose To estimate the association between red blood cell (RBC) transfusion volume and hospital-acquired infections (HAI) in critically ill patients, with a particular focus on identifying the potential threshold volumes at which infection risk changes.
Shodai Yoshihiro, Yuki Kataoka, Takashi Hongo, Takahiro Tsuge, Hiroaki Matsuo   +4 more
doaj   +1 more source