Results 61 to 70 of about 2,709,505 (306)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Joint associations of air pollutants during pregnancy, infancy, and childhood with childhood persistent asthma: Nationwide database study in Japan

Ecotoxicology and Environmental Safety
The joint effect of air pollutants at relatively low levels requires further investigation. Here, a database study was performed to evaluate the effects of exposure to mixtures of air pollutants during pregnancy, infancy, and childhood on childhood ...
Akihiro Shiroshita, Yuki Kataoka, Qianzhi Wang, Naoki Kajita, Keisuke Anan, Takumi Tajima, Nobuyuki Yajima   +6 more
doaj   +1 more source

A method and tool to support the analysis and enhance the understanding of peer-­to-­peer learning experiences [PDF]

, 2010
In this paper we look at how a web-based social software can be used to make qualitative data analysis of online peer-to-peer learning experiences. Specifically, we propose to use Cohere, a web-based social sense-making tool, to observe, track, annotate ...
Alevizou, Panagiota, De Liddo, Anna
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Představy o mužském/chlapeckém vzhledu ve školních třídách [PDF]

Gender a Výzkum, 2013
The article is focuses on the adolescent concept of male/boy appearance and its impact on the social position of boys in a classroom structure. Boys can reach a better social position if their appearance corresponds to group norms.
Irena Smetáčková, Helena Čechová, Karolína Klasová, Barbora Slavíčkvoá   +3 more
doaj  

SPARKPLUS for Self- and Peer Assessment on Group-Based Honours’ Research Projects [PDF]

, 2010
This paper explores an application of an online tool SPARKPLUS (Self and Peer Assessment Resource Kit) for the self and peer assessment on the group-based Honours’ research projects.
Chanda, E., Willison, J., Wu, C.
core   +1 more source

Peer Education to Promote HPV Vaccine Uptake in Philly Teens [PDF]

, 2020
The human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. Almost half of HPV infections occur in teens and young adults and can lead to various types of cancers.
Bindra, Riva, Leader, DrPH, MPH, Amy
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploiting peer group concept for adaptive and highly available services

, 2003
This paper presents a prototype for redundant, highly available and fault tolerant peer to peer framework for data management. Peer to peer computing is gaining importance due to its flexible organization, lack of central authority, distribution of ...
Ali, Arshad, Fraz, Mohammad Moazam, Jan, Muhammad Asif, Zahid, Fahd Ali   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source