Results 71 to 80 of about 11,026,307 (286)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Tree-connected Peer Group Situations and Peer Group Games [PDF]
, 2000 A class of cooperative games is introduced which arises from situations in which a set of agents is hierarchically structured and where potential individual economic abilities interfere with the behavioristic rules induced by the organization structure ...
Brânzei, R., Tijs, S.H., Fragnelli, V.
core +1 more source
Představy o mužském/chlapeckém vzhledu ve školních třídách [PDF]
Gender a Výzkum, 2013 The article is focuses on the adolescent concept of male/boy appearance and its impact on the social position of boys in a classroom structure. Boys can reach a better social position if their appearance corresponds to group norms.
Irena Smetáčková +3 more
doaj
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Leadership in Peer Group Mentoring
International Journal of Evidence Based Coaching and MentoringIn traditional one-to-one mentoring relationships, the mentor is typically perceived as the leader and the mentee serves as a follower. In peer group mentoring experiences, traditional notions of top-down leadership and hierarchical decision-making are ...
Jonathan Kroll, Regina M. O’Neill
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Peer Effects and Pupil Attainment: Evidence from Secondary School Transition [PDF]
It is a common belief that children will thrive if educated amongst better class and schoolmates. It is a belief that guides many parents in their choice of school, and has important implications for policy on school choice and organisation. Many studies
Shqiponja Telhaj, Steve Gibbons
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Peer effects in English Primary schools: An IV estimation on the effect of a more able peer group on age 11 examination results [PDF]
The magnitude and characteristics of the effect of a child’s peers on their outcomes has long interested researchers and policy makers. In this paper, I take advantage of the correlation between the average outcomes a child’s peer group attains with the ...
Steven Proud
core