Results 171 to 180 of about 984,880 (314)

Effectiveness of peer support interventions to improve mental health outcomes after miscarriage: a systematic review and call for high-quality evidence. [PDF]

BMJ Open
Burton L, Charles J, Cherry MG, Corcoran R, Hassan S, Hill R, Little S, Maden M, Mulholland H, Perkins E, Slade P, Wallis S, Marshall P.   +12 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

'He who knows it, feels it.' Stepping stones towards fulfilling a peer-advocate role among people with chronic stigmatising conditions in Liberia. [PDF]

Int Health
Berrian H, McCollum R, Seekey W, Godwin-Akpan TG, Zaizay Z, Theobald S, Dean L.   +6 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Integrating community Live Reviews into academic publishing: an exploratory study. [PDF]

Res Integr Peer Rev
Petkov CI, Fairhurst V, Granados M, Chudasama Y, Rodney G, Jabeen SA, David S, Mitchell AS, Klink PC, Mehmani B, Saderi D.   +10 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An assessment of the African peer review mechanism (APRM) : the case of Nigeria [PDF]

This thesis assesses the African Peer Review Mechanism (APRM) as it has played out in Nigeria. The APRM is an initiative by the African Union (AU) and the New Partnership for Africa's Development (NEPAD) to promote good governance through self ...
Khalil, Mouzayian
core  

Mapping of mental health indicators in the WHO European region: a scoping review. [PDF]

BMJ Health Care Inform
Abdul Ghaffar H, Adib K, Redlich C, Tijhuis M, Boekelman F, Koopman N, Miedema J, Lazeri L, Novillo-Ortiz D.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Introducing COSIG: The Collection of Open Science Integrity Guides. [PDF]

PLoS Biol
Ozturk Y, Pirelli S, Richardson RAK.
europepmc   +1 more source