Results 91 to 100 of about 12,310,539 (395)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Chinese Medicine in the Management of New and Emerging Infectious Diseases

open access: yesDigital Chinese Medicine, 2018
: Emerging infectious diseases are an important problem in medicine, and many continue to pose a global threat. However, the management of new and emerging infections is usually difficult due to a lack of knowledge and tools to address the problem.
Viroj Wiwanitkit
doaj  

Peer Review and the PJOHNS: Principles, Problems, and Promise

open access: yesPhilippine Journal of Otolaryngology Head and Neck Surgery, 2018
The Philippine Journal of Otolaryngology Head and Neck Surgery (PJOHNS) is the official refereed journal of the Philippine Society of Otolaryngology Head and Neck Surgery (PSOHNS).
José Florencio F. Lapeña
doaj   +1 more source

The Convergence of Digital-Libraries and the Peer-Review Process

open access: yes, 2005
Pre-print repositories have seen a significant increase in use over the past fifteen years across multiple research domains. Researchers are beginning to develop applications capable of using these repositories to assist the scientific community above ...
B. Gitanjali   +16 more
core   +2 more sources

How should peer-review panels behave? [PDF]

open access: yes, 2012
Many governments wish to assess the quality of their universities. A prominent example is the UK’s new Research Excellence Framework (REF) 2014. In the REF, peer-review panels will be provided with information on publications and citations.
Andrew J. Oswald   +41 more
core   +6 more sources

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

Auctions and Peer Prediction for Academic Peer Review [PDF]

open access: yesarXiv, 2021
Peer reviewed publications are considered the gold standard in certifying and disseminating ideas that a research community considers valuable. However, we identify two major drawbacks of the current system: (1) the overwhelming demand for reviewers due to a large volume of submissions, and (2) the lack of incentives for reviewers to participate and ...
arxiv  

The Coupled Cluster Method Applied to Quantum Magnets: A New LPSUB$m$ Approximation Scheme for Lattice Models [PDF]

open access: yes, 2010
A new approximation hierarchy, called the LPSUB$m$ scheme, is described for the coupled cluster method (CCM). It is applicable to systems defined on a regular spatial lattice.
Bishop, R F, Li, P H Y
core   +2 more sources

The changing forms and expectations of peer review

open access: yesResearch Integrity and Peer Review, 2018
The quality and integrity of the scientific literature have recently become the subject of heated debate. Due to an apparent increase in cases of scientific fraud and irreproducible research, some have claimed science to be in a state of crisis.
S. Horbach, W. Halffman
semanticscholar   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

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