Results 81 to 90 of about 11,761,789 (305)

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Developing a cognitive conservation model for the management of Malaysian birders' behavior toward birds

Frontiers in Sustainable Tourism
IntroductionBirdwatching as a subcategory of ecotourism can create recreational disturbance. This research aims to assess two main goals: firstly, the effects of the frequency of participation (FOP) of Malaysian birders as moderators on the constructs of
Marjan Jafarpour, Haywantee Ramkissoon, Haywantee Ramkissoon, Haywantee Ramkissoon, Haywantee Ramkissoon   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

From concept to regulation: OECD’s role in the development of the DNT in vitro battery

Frontiers in Toxicology
Chemical exposure during critical stages of nervous system development can lead to adverse neurotoxic effects, known as developmental neurotoxicity (DNT).
Magdalini Sachana, Helena T. Hogberg, Iris Mangas   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The effect of publishing peer review reports on referee behavior in five scholarly journals

Nature Communications, 2019
To increase transparency in science, some scholarly journals are publishing peer review reports. But it is unclear how this practice affects the peer review process.
Giangiacomo Bravo, F. Grimaldo, E. López-Iñesta, B. Mehmani, F. Squazzoni   +4 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Blockchain-enabled KYC integration for CLV optimization with robust M-Estimation and IRLS method

ICT Express
This research introduces an innovative approach in implementing Know Your Customer (KYC) on blockchain technology as a means of using data, hybrid robust m-estimation, and the iteratively reweighted less squares (IRLS) method to optimize CLV data.
Marischa Elveny, Mahyuddin K.M. Nasution, Fanindia Purnamasari, Tengku Siti Meriam Tengku Wook   +3 more
doaj   +1 more source

Gender differences in peer review outcomes and manuscript impact at six journals of ecology and evolution

Ecology and Evolution, 2019
The productivity and performance of men is generally rated more highly than that of women in controlled experiments, suggesting conscious or unconscious gender biases in assessment.
C. W. Fox, C. E. T. Paine
semanticscholar   +1 more source