Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
From concept to regulation: OECD’s role in the development of the DNT in vitro battery
Frontiers in ToxicologyChemical exposure during critical stages of nervous system development can lead to adverse neurotoxic effects, known as developmental neurotoxicity (DNT).
Magdalini Sachana +2 more
doaj +1 more source
Rethinking Resource Allocation in Science
, 2019 US funding agencies alone distribute a yearly total of roughly $65B dollars largely through the process of proposal peer review: scientists compete for project funding by submitting grant proposals which are evaluated by selected panels of peer reviewers.
Bollen, Johan +3 more
core +1 more source
The frustrated Heisenberg antiferromagnet on the honeycomb lattice: A candidate for deconfined quantum criticality [PDF]
, 2011 We study the ground-state (gs) phase diagram of the frustrated spin-1/2 $J_{1}$-$J_{2}$-$J_{3}$ antiferromagnet with $J_{2} = J_{3} =\kappa J_1$ on the honeycomb lattice, using coupled-cluster theory and exact diagonalization methods.
Bishop, R. F. +4 more
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
PeerPigeon: A Web Application to Support Generalised Peer Review
, 2008 Peer Review (also known as Peer Assessment) is an important technique in learning, but can be difficult to support through e-learning due to the complexity and variety of peer review processes.
Millard, David +2 more
core
Spin-1/2 Heisenberg antiferromagnet on an anisotropic kagome lattice [PDF]
, 2012 We use the coupled cluster method to study the zero-temperature properties of an extended two-dimensional Heisenberg antiferromagnet formed from spin-1/2 moments on an infinite spatially anisotropic kagome lattice of corner-sharing isosceles triangles ...
Bishop, R. F. +5 more
core +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Blockchain-enabled KYC integration for CLV optimization with robust M-Estimation and IRLS method
ICT ExpressThis research introduces an innovative approach in implementing Know Your Customer (KYC) on blockchain technology as a means of using data, hybrid robust m-estimation, and the iteratively reweighted less squares (IRLS) method to optimize CLV data.
Marischa Elveny +3 more
doaj +1 more source
Joint Report of Peer Review Panel for Numeric Nutrient Criteria for the Great Bay Estuary New Hampshire Department of Environmental Services June, 2009 [PDF]
, 2014 This peer review was authorized through a collaborative agreement sponsored by the New Hampshire Department of Environmental Services (DES) and the Cities of Dover, Rochester and Portsmouth, New Hampshire.
Bierman, Victor J. +3 more
core +1 more source