Results 71 to 80 of about 11,761,789 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Constitution Identification System for Traditional Chinese Medicine (TCM) Based on Correlation Between TCM Constitution and Physical Examination Indices

Digital Chinese Medicine, 2018
: Objective Identification of one’s constitution based on a combination of features and back propagation neural network theory is needed in modern medicine and traditional Chinese medicine (TCM).
Yue Luo, Bing Lin, Chuan-Biao Wen, Jie-Lin He   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Pediatric Orthopaedic Clinical Peer-review Triggers and Ongoing Professional Practice Evaluation (OPPE) Metrics: An Ohio Statewide Consensus

Journal of the Pediatric Orthopaedic Society of North America
Background: Two critical mechanisms to measure competency in pediatric orthopaedic surgery are case-based clinical peer review and ongoing professional practice evaluation (OPPE). However, we currently lack a standard set of triggers or metrics to inform
Julie B. Samora, MD, PhD, Kevin Baker, RN, Kerwyn Jones, MD, Michael Vish, MD, Susan P. Tourner, MD, Michael Vossmeyer, MD, Nichole Liston, RN, Todd F. Ritzman, MD, Michael T. Bigham, MD, MBA   +8 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Governing the Game-Changer: Reimagining Peer Review in the Age of AI

Trends in Scholarly Publishing
The peer review system, long regarded as the cornerstone of scholarly publishing, is facing unprecedented strain. Rising submission volumes, reviewer fatigue, and increasing instances of research misconduct have revealed deep structural vulnerabilities ...
Lucy Threadgold, Hong Zhou, Simone Ragavooloo, Daniel Stuckey, Maryam Sayab   +4 more
doaj   +1 more source

Peer Feedback Tool for Lectures & Small-Group Teaching

MedEdPORTAL, 2011
This resource is a teaching assessment tool designed to provide faculty members with information about the quality of their teaching based on peer observation.
Maria Blanco, Carol Capello, Maryellen Gusic, Wayne McCormack, Janet Hafler   +4 more
doaj   +1 more source

In Appreciation: A Thank-You to Our Industrious Reviewers

Marshall Journal of Medicine, 2022
The reputation of the Marshall Journal of Medicine depends on the authors' contribution; however, the standard of the Journal's level of excellence is also a consequence of the efforts of expert peer reviewers.
Darshana T. Shah
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Maintaining Live Discussion in Two-Stage Open Peer Review

Frontiers in Computational Neuroscience, 2012
Open peer review has been proposed for a number of reasons, in particular, for increasing the transparency of the article selection process for a journal, and for obtaining a broader basis for feedback to the authors and for the acceptance decision.
Erik eSandewall, Erik eSandewall
doaj   +1 more source