Results 41 to 50 of about 394,545 (303)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Women’s experience with peer counselling and social support during a lifestyle intervention among women with a previous gestational diabetes pregnancy

open access: yesHealth Psychology and Behavioral Medicine, 2019
Purpose Women who are diagnosed with gestational diabetes mellitus have an increased risk of developing type 2 diabetes, but most receive little guidance regarding disease prevention.
Meghan S. Ingstrup   +6 more
doaj   +1 more source

Creating Hope Through Employment for People Who are Homeless or in Transitional Housing [PDF]

open access: yes, 2005
[Excerpt] Persons with significant disabilities, especially those with problems relating to mental illness and/or substance abuse, face numerous challenges in securing employment.
Marrone, Joe
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

“It’s more than a ride” veteran perceptions of peer specialist qualities and activities that were most valuable for post-incarceration reentry: a qualitative analysis

open access: yesHealth & Justice
Background Reentry veterans experience many barriers to achieving physical and psychological well-being. While peer specialists can provide important support to veterans as they readjust to life post-incarceration, their specific activities and qualities
Eric Richardson   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Physical and mental health of behavioural health certified peer specialists in four US states

open access: yesBMJ Mental Health
Background Little is known about the health and healthcare needs of the behavioural health peer specialist workforce in the USA. This study explored the physical and mental health-related quality of life (QOL) of a US multistate cohort of certified peer ...
Judith A Cook   +4 more
doaj   +1 more source

Implementing an mhGAP-based training and supervision package to improve healthcare workers’ competencies and access to mental health care in Malawi

open access: yesInternational Journal of Mental Health Systems, 2020
Background It is now well established that the integration of mental health care into primary care is one of the most effective ways of reducing the substantial treatment gap for mental disorders which exists in most low- and middle-income countries ...
Jen Ahrens   +11 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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