Results 61 to 70 of about 394,545 (303)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Empowering Non-Specialist English Teachers: Self-Efficacy Enhancement Through Classroom English Proficiency and Collaborative Support

Education Sciences
The increase in the provision of English language teaching programs in primary school contexts in Asia has resulted in a concomitant increase in non-specialist teachers, often generalist homeroom teachers, to address the shortage. However, non-specialist
Shoichi Matsumura, Yushi Hinoki
doaj   +1 more source

Engaging Nursing Staff in Research: The Clinical Nurse Specialist Role in an Academic-Clinical Partnership [PDF]

, 2016
Purpose: The purpose of this article is to describe the processes of exploring and implementing an academic-clinical study, engaging nursing staff in research, and maintaining their enthusiasm within the context of an academic-clinical research ...
Boaz, Lesley, Bull, Margaret J., Gettrust, Lynn, Hagle, Mary E.   +3 more
core   +1 more source

Automatically detecting open academic review praise and criticism [PDF]

, 2020
This is an accepted manuscript of an article published by Emerald in Online Information Review on 15 June 2020. The accepted version of the publication may differ from the final published version, accessible at https://doi.org/10.1108/OIR-11-2019-0347.
Allen, Liz, Nyakoojo, Zena, Papas, Eleanor-Rose, Thelwall, Michael, Weigert, Verena   +4 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The role of social networks in supporting self-management in CKD: a narrative synthesis

BMC Nephrology
Background Chronic kidney disease (CKD) is a growing global health concern requiring effective self-management to mitigate progression and improve quality of life.
Becky Bonfield, Kristin Veighey, Tom Blakeman, Emma Murphy, Ivaylo Ivanov Vassilev   +4 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Lived Experience of Parastomal Bulging: A Mixed Methods Study

Journal of Abdominal Wall Surgery
Aim:This United Kingdom study aimed to explore people’s experiences of living with, and self-managing parastomal bulging.Methods:Seventeen people were interviewed and 61 people completed an online survey.Results:Parastomal bulging has a detrimental ...
Julie Munro, Gill Hubbard, Will Goodman, Rebecca Beeken, Raymond Oliphant   +4 more
doaj   +1 more source

Effectiveness and cost-effectiveness of out-of-hours palliative care: a systematic review [version 1; peer review: 2 approved]

HRB Open Research, 2020
Background: Out-of-hours palliative care is a priority for patients, caregivers and policymakers. Approximately three quarters of the week occurs outside of typical working hours, and the need for support in care of serious and terminal illness during ...
Bridget M. Johnston, Rachel McCauley, Regina McQuillan, Mary Rabbitte, Caitriona Honohan, David Mockler, Steve Thomas, Peter May   +7 more
doaj   +1 more source

"A place where I can be me": a role for social and leisure provision to support young people with language impairment [PDF]

, 2011
The long-term well-being of children with language impairment is an area of increasing interest to families, educators and employers as language impairment is often life-long.
Adams, Adams, Beitchman, Botting, Botting, Brinton, Brownlie, Clegg, Conti-Ramsden, Conti-Ramsden, Cummings, Dempsey, Department for Children, Schools and Families, Department for Education and Skills, Dockrell, Durkin, Farmer, Fujiki, Goodman, Gregory, Horowitz, Howlin, Johnson, Knox, McCabe, Palikara, Paul, Pratt, Ratner, Redmond, Snowling, Stevenson, Voci, Wadman   +33 more
core   +1 more source