Results 101 to 110 of about 1,249,395 (277)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Effects of Parental Nurturing Attitudes, Peer Victimization, and Depressive Rumination on Anxiety in Japanese Adults

Psychiatry International
Parental attitudes and peer victimization experiences in childhood influence anxiety. Depressive rumination is associated with these factors, but the interrelationship between them remains unclear. In this study, we hypothesized that “inadequate parental
Jiro Masuya, Masayuki Kikkawa, Miki Ono, Chihiro Morishita, Shunichiro Ito, Rintaro Nibuya, Yu Tamada, Osamu Takashio, Mina Honyashiki, Takeshi Inoue   +9 more
doaj   +1 more source

A multivariate analysis of gun violence among urban youth: The impact of direct victimization, indirect victimization, and victimization among peers

Cogent Social Sciences, 2017
Research suggests that many adolescents involved in violence as victims become offenders themselves as they are exposed to increased levels of indirect victimization, direct victimization, and peer victimization.
Zina T. McGee, Kyle Logan, Joseph Samuel, Tandeka Nunn   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Who are the victims of peer violence?

Zbornik Instituta za pedagoska istrazivanja, 2013
Peer violence is a very current problem in schools. There are plenty of studies on the characteristics of perpetrators, while the characteristics of victims have been explored much less frequently. This research was aimed at determining the factors from the domain of upbringing and socio-demographic characteristics of the victims that ...
Nedimović Tanja, Biro Mikloš
openaire   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

PEER VICTIMIZATION, DEPRESSIVE SYMPTOMS AND ACADEMIC FUNCTIONING IN SCHOOL CHILDREN

Pakistan Armed Forces Medical Journal, 2018
Objective: To determine the prevalence of peer victimization in school children, its relationship with depressive symptoms and academic functioning along with demographic differences (gender and grade) among study variables.
Nazia Mustafa
doaj   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source