Results 61 to 70 of about 18,881 (295)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mapping Developmental Precursors of Cyber-Aggression: Trajectories of Risk Predict Perpetration and Victimization

, 2013
Technologically mediated contexts are social arenas in which adolescents can be both perpetrators and victims of aggression. Yet, there remains little understanding of the developmental etiology of cyber aggression, itself, as experienced by either ...
Barber, B.L., Vernon, Lynnette, Vernon, Lynette, Barber, B., Modecki, Kathryn L, Modecki, K.L., Modecki, K., Vernon, L., Barber, Bonnie L, Modecki, Kathryn L., Barber, Bonnie L.   +10 more
core   +1 more source

Peer victimization, depressive symptoms and non-suicidal self-injury behavior in Chinese migrant children: the roles of gender and stressful life events

Psychology Research and Behavior Management, 2019
Quanquan Wang, Xia LiuInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, People’s Republic of ChinaBackground: Non-suicidal self-injury (NSSI) has become a worldwide health concern, especially for the ...
Wang Q, Liu X
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Peer victimization in Korean male middle school students: The influence of parental bonding and mental health

KEDI Journal of Educational Policy, 2016
Although the connection between parental bonding and adolescent peer victimization is widely accepted, little is known about the specific mechanism underlying this link.
Donghun Lee, HaeJin Shin
doaj   +1 more source

The Vicissitudes of Homophobic Victimization in Adolescence: An Explorative Study

Frontiers in Psychology, 2020
This study investigates the role of parental and peer relationships’ quality on homophobic victimization and possible consequences on mental health during adolescence. Participants were 394 adolescents, (41.6% male and 58.4% female) aged 15–20 years (M =
Ugo Pace, Giulio D’Urso, Lilybeth Fontanesi   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Peer victimization and non-suicidal self-injury among high school students: the mediating role of social anxiety, mobile phone addiction, and sex differences

BMC Psychiatry
Background Peer victimization (PV) is one of the major causes of non-suicidal self-injury. Non-suicidal self-injury (NSSI), peer victimization, social anxiety, and mobile phone addiction are significantly related; however, the interaction mechanism and ...
Qianmei Long, Bin Huang, Yiyu Tang, Junlin Wu, Jia Yu, Junlin Qiu, Yanqing Huang, Guoping Huang   +7 more
doaj   +1 more source

Peer victimization as reported by children, teachers, and parents in relation to children's health symptoms

BMC Public Health, 2011
Background Victims of bullying in school may experience health problems later in life. We have assessed the prevalence of children's health symptoms according to whether peer victimization was reported by the children, by their teachers, or by their ...
Mæhle Magne, Paulsen Bård, Lydersen Stian, Løhre Audhild, Vatten Lars J   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source