Results 51 to 60 of about 10,402 (207)

Fabrication of Doxorubicin-Loaded Lipid-Based Nanocarriers by Microfluidic Rapid Mixing

Biomedicines, 2022
Doxorubicin (Dox) is a widely known chemotherapeutic drug that has been encapsulated into liposomes for clinical use, such as Doxil® and Myocet®. Both of these are prepared via remote loading methods, which require multistep procedures.
Chia-Ying Lee, Tsuimin Tsai, Po-Chun Peng, Chin-Tin Chen   +3 more
doaj   +1 more source

PEG Alternatives in Liposomal Nanocarriers: Physicochemical Characteristics and Sustainable Process Strategies

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The global trend toward sustainable and intensified bioprocesses is driving innovation in the design and scalable synthesis of liposomal nanocarriers, a cornerstone of modern drug delivery. For decades, these nanosystems have relied exclusively on polyethylene glycol (PEG) for their sustained circulation in vivo, but they are currently ...
Chandra Has
wiley   +1 more source

PEGylated Liposomes Remotely Loaded with the Combination of Doxorubicin, Quinine, and Indocyanine Green Enable Successful Treatment of Multidrug-Resistant Tumors

Pharmaceutics, 2021
Multidrug resistance (MDR) of cancer cells remains a major obstacle to favorable outcomes of treatment with many drugs, including doxorubicin. Most of the clinical trials failed to demonstrate the benefit of the drug efflux transporter P-glycoprotein (P ...
Emma Grabarnick (Portnoy), Alexander V. Andriyanov, Hadas Han, Sara Eyal, Yechezkel Barenholz   +4 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Incidence of Palmar-Plantar Erythrodysesthesia in Pretreated and Unpretreated Patients Receiving Pegylated Liposomal Doxorubicin

, 2009
Aims and Background Association between pegylated liposomal doxorubicin-based regimens and palmar-plantar erythrodysesthesia have just been emphasized, whereas the relationship between previous treatment and palmar-plantar erythrodysesthesia is still a ...
Roberto Sorio, Ettore Bidoli, Simona Scalone, GianMaria Miolo, Andrea Veronesi, Paolo Baldo, Davide Lombardi   +6 more
core   +1 more source

Liposomal doxorubicin as targeted delivery platform: Current trends in surface functionalization

, 2020
Liposomal delivery systems have significantly enhanced the efficacy and safety of chemotherapeutic agents compared to free (non-liposomal) formulations.
Makwana, Vivek, Karanjia, Jasmine, Haselhorst, Thomas, Anoopkumar-Dukie, Shailendra, Rudrawar, Santosh   +4 more
core   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Efficacy of chemotherapeutics in classic and non-classic Kaposi sarcoma: A single-center retrospective real-world data

Biomolecules & Biomedicine, 2021
Kaposi sarcoma is a rare disease and there is a gap in the literature about which chemotherapeutics should be applied, especially for the classical type.
Sibel Oyucu Orhan, Ahmet Bilgehan Sahin, Erdem Cubukcu, Adem Deligonul, Birol Ocak, Bedrettin Orhan, Turkkan Evrensel   +6 more
doaj   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source