Results 31 to 40 of about 288 (101)

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Cancer metabolism is a field focused on the unique alterations in metabolic pathways that occur in cancer cells, distinguishing them from the metabolic processes in normal cells. Methods An extensive review of the current literature on the metabolic adaptation of cancer cells was carried out in the current study. Results The rapidly
Jilsy M. J. Punnasseril, Abdul Auwal, Vinod Gopalan, Alfred King‐Yin Lam, Farhadul Islam   +4 more
wiley   +1 more source

ИСПОЛЬЗОВАНИЕ ПИРИДОКСИНА ДЛЯ ПОВЫШЕНИЯ ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТИ МЕТИОНИН-ГАММАЛИАЗЫ НА МОДЕЛЯХ ПЕРЕВИВАЕМЫХ ОПУХОЛЕЙ МЫШЕЙ

, 2017
We presented results of monotherapy and combination therapy of transplantable murine tumor models using methionine-gamma-lyase (MGL) and pyridoxine hydrochloride. We studied MGL from Clostridium sporogenes and Citrobacter freundii.
Е. А. Morozova, И. В. Манухов, Д. Ж. Давыдов, Н. В. Ануфриева, Г. Б. Завильгельский, D. Zh. Davydov, Т. В. Демидкина, I. V. Manukhov, Е. А. Морозова, Е. М. Трещалина, М. V. Komarova, T. V. Demidkina, Е. М. Treshchalina, В. С. Покровский, N. V. Anufrieva, М. В. Комарова, V. S. Pokrovsky, G. B. Zavilgelsky   +17 more
core   +1 more source

Пэгилирование как метод создания пролонгированных форм биофармацевтических препаратов (на примере пэгилированного гранулоцитарного колониестимулирующего фактора)

, 2014
By now the pegylation of biologically active molecules including proteins with an inert hydrophilic polymer polyethylene glycol (PEG) is an important area in the new generation of prolonged-action pharmaceutical preparations.
V. I. Shvets, Д. И. Баирамашвили, I. А. Puchkov, D. I. Bairamashvili, В. И. Швец, И. А. Пучков   +5 more
core   +1 more source

Agricultural nanotechnology for a safe and sustainable future: current status, challenges, and beyond

Journal of the Science of Food and Agriculture, Volume 105, Issue 6, Page 3159-3169, April 2025.
Abstract Nanotechnology, which involves manipulating matter at the atomic and molecular scales to produce structures and devices ranging from 1 to 100 nm, is increasingly being applied in agriculture. Nanoscale materials possess distinct optical, electrochemical, and mechanical properties that enable the smart, targeted delivery of pesticides ...
Pamela Aracena Santos, Xhulja Biraku, Erik Nielsen, Ahmet Caglar Ozketen, Ayse Andac Ozketen, Erdogan Esref Hakki   +5 more
wiley   +1 more source

State‐of‐the‐art 2023 on gene therapy for phenylketonuria

Journal of Inherited Metabolic Disease, Volume 47, Issue 1, Page 80-92, January 2024.
Abstract Phenylketonuria (PKU) or hyperphenylalaninemia is considered a paradigm for an inherited (metabolic) liver defect and is, based on murine models that replicate all human pathology, an exemplar model for experimental studies on liver gene therapy.
Michael Martinez, Cary O. Harding, Gerald Schwank, Beat Thöny   +3 more
wiley   +1 more source

Développement d’hydrogels poreux pour la formulation orale d’une enzyme thérapeutique

Les hydrogels sont des réseaux de polymères hydrophiles réticulés qui ont fait l'objet de recherches approfondies dans un grand nombre de domaines, notamment la formulation pharmaceutique, la réparation de tissus, le diagnostic, les cosmétiques et même l'
Delbreil, Philippe
core   +1 more source

Pegvaliase: Immunological profile and recommendations for the clinical management of hypersensitivity reactions in patients with phenylketonuria treated with this enzyme substitution therapy

, 2019
OBJECTIVE: To provide recommendations for managing hypersensitivity adverse events (HAEs) to an injectable enzyme substitution therapy (pegvaliase, a PEGylated phenylalanine ammonia lyase enzyme) in adult patients with phenylketonuria (PKU).
Daha, Mohamed, Brockow, Knut, Northrup, Hope, Longo, Nicola, Knol, Edward, Hausmann, Oliver, Müller, Ingo   +6 more
core  

Abstracts

Molecular Oncology, Volume 18, Issue S1, Page 1-495, June 2024.
wiley   +1 more source