Results 141 to 150 of about 20,314 (255)

Melanin Nanoparticles as a Safe and Effective Iron Chelation Therapy: An ex vivo Assessment of Placental Transfer in Pregnant Beta-Thalassemia

International Journal of Nanomedicine
Nahla Bakhamis,1 Toluwalase Awoyemi,1 Manu Vatish,1 Helen Townley1,2 1Nuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, UK; 2Department of Engineering Science, University of Oxford, Oxford, UKCorrespondence ...
Bakhamis N, Awoyemi T, Vatish M, Townley H   +3 more
doaj  

Pegylated NIR Fluorophore-Conjugated OBHSA Prodrug for ERα-Targeted Theranostics with Enhanced Imaging and Long-Term Retention

Molecules
In recent years, the near-infrared (NIR) fluorescence theranostic system has garnered increasing attention for its advantages in the simultaneous diagnosis- and imaging-guided delivery of therapeutic drugs.
Xiaohua Wang, Xiaofei Deng, Lilan Xin, Chune Dong, Guoyuan Hu, Hai-Bing Zhou   +5 more
doaj   +1 more source

Evolution of N‐terminal mechanical lability as a determinant for Type III secretion

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Many Gram‐negative pathogens critically depend on the Type III secretion system (T3SS) to inject effector proteins into host cells for colonization. Because the channel of the T3SS is narrow (~2 nm), effectors must be unfolded for secretion.
Katherine E. DaPron, Alexandre M. Plastow, Morgan R. Fink, Brandon Dzuba, Marc‐Andre LeBlanc, Thomas T. Perkins, Emad Tajkhorshid, Marcelo C. Sousa   +7 more
wiley   +1 more source

DNA‐mimic for Specific Surface Functionalization of Zr‐MOFs for Bacterial Targeting

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
We introduce phosphotyrosine‐modified PNA as a superior, single‐step post‐synthesis surface coating for PCN‐222. The DNA mimic allows for controlled post‐functionalization with single‐stranded DNA for the attachment of protein moieties for bacterial targeting. ABSTRACT Nanosized metal–organic frameworks (MOFs) are versatile platforms used in biomedical
Anna Scheeder, Jon Ostolaza‐Paraiso, Andrew G. Baker, Juan F. Blandez, Georgina E. Lindop, Simon M. Fairclough, Ljiljana Fruk, Ioanna Mela, David Fairen‐Jimenez, Clemens F. Kaminski   +9 more
wiley   +2 more sources

Host–Guest Interactions Govern Drug Stability and Controlled Therapeutic Release: Based on Metal–Organic Frameworks as Smart Platforms

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT Due to their exceptional porosity, structural versatility, and modular coordination chemistry, metal–organic frameworks (MOFs) have emerged as versatile platforms for targeted drug delivery. These structures enable fine‐tuning of pore size, surface activity, and framework stability for the encapsulation of a broad range of therapeutics ...
Rui Hua, Kai You, Qifang Liu, Mengjie Chen, Li Sun, Aochi Liu, Jie Lin, Yang Song, Shasha Yu, Haishan Zhang   +9 more
wiley   +1 more source

Metal‐Based Materials for Redox Modulation in Biomedicine

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT Metal materials have become increasingly important in modulating biological redox networks for therapeutic and diagnostic purposes, owing to their distinctive electronic properties and adaptable reactivity. This review synthesizes recent developments across various metal‐based materials, including elemental metals, metal oxides, coordination ...
Yan Fan, Jing Zhang, Ning Sun, Mengjie Chen, Li Sun, Jie Lin, Kang Chen, Haishan Zhang   +7 more
wiley   +1 more source

PEGylation, successful approach to drug delivery. [PDF]

, 2005
PEGylation defines the modification of a protein, peptide or non-peptide molecule by the linking of one or more poly(ethylene glycol) (PEG) chains. This polymer appeared the best choice being non-toxic, non-immunogenic, non-antigenic, highly soluble in ...
PASUT, GIANFRANCO, VERONESE FM
core  

PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications

Open Life Sciences
The growing prevalence of hyperuricemia necessitates the urgent development of more potent treatments. This study aimed to develop, optimize, and evaluate the safety and efficacy of porcine–human recombinant uricase (PHRU) both in vitro and in vivo.
Wang Xiangyan, Lu Hao, Rong Jun, Sun Zhongjie, Zheng Yanhua, Fan Bolin, Jia Ziming   +6 more
doaj   +1 more source

Sonosensitizer‐Functionalized Polymetallic Nanoenzymes for Photoacoustic Imaging‐Guided Cancer Sonodynamic Immunotherapy

SmartMat, Volume 7, Issue 4, August 2026.
A sonosensitizer‐functionalized polymetallic nanozyme PPBCH enables photoacoustic imaging‐guided sonodynamic cancer immunotherapy. Upon US irradiation activation, the nanozyme amplifies oxidative stress by generating O2, producing ROS, and depleting glutathione, thereby inducing ferroptotic stress and immunogenic cell death.
Caiying Li, Fangyi Pang, Yuzhen Ma, Yidong Bin, Lixian Huang, Jingjin Zhao, Mengjiao Huang, Jinzhe Liang, Liangliang Zhang, Shulin Zhao, Hong Liang   +10 more
wiley   +1 more source

Engineered Bacterial Membranes as Next‐Generation Platforms for Cancer Immunotherapy

Small Science, Volume 6, Issue 8, August 2026.
Engineered bacterial membrane platforms, including outer membrane vesicles, bacterial ghosts, genetically engineered membranes, and hybrid bacterial–tumor membranes, integrate tumor antigen presentation with intrinsic immune stimulation. These platforms promote dendritic‐cell activation, T‐cell priming, pyroptosis, and synergistic responses with ...
Hafiza Aasia Malik, Urooj Yousaf Virk, Mohamed Salah Attia, Jenny Wilson, Ming Wei   +4 more
wiley   +1 more source