Results 141 to 150 of about 32,225 (250)

Laser Engineering of HfN‐Based Nanoparticles for Safe NIR‐I Photothermal and X‐ray Enhancing Cancer Therapies

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
In this study, we produced HfN‐based nanoparticles via femtosecond laser ablation in acetone. The nanoparticles exhibit a red‐shifted plasmonic resonance in the NIR‐I window, colloidal stability after coating with polyethyleneglycol, and excellent biocompatibility. The photothermal and X‐ray sensitization therapeutic effects were demonstrated for tumor
Julia S. Babkova, Ivan V. Zelepukin, Lyubov V. Gorelik, Anton L. Popov, Andrei I. Pastukhov, Gleb V. Tikhonowski, Maxim S. Savinov, Danil D. Kolmanovich, Nikita A. Pivovarov, Alina Yu. Kapitannikova, Anton A. Popov, Anna S. Sogomonyan, Vsevolod A. Skribitsky, Aziz B. Mirkasymov, Andrei V. Kabashin, Sergey M. Deyev   +15 more
wiley   +1 more source

Pegylation [PDF]

, 2020
openaire   +1 more source

PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications

Open Life Sciences
The growing prevalence of hyperuricemia necessitates the urgent development of more potent treatments. This study aimed to develop, optimize, and evaluate the safety and efficacy of porcine–human recombinant uricase (PHRU) both in vitro and in vivo.
Wang Xiangyan, Lu Hao, Rong Jun, Sun Zhongjie, Zheng Yanhua, Fan Bolin, Jia Ziming   +6 more
doaj   +1 more source

Site-Specific PEGylation of Recombinant Immunotoxin DAB389IL-2: Structural and Functional Assessment

Research in Molecular Medicine, 2019
Background: DAB389IL-2 is considered a fusion immunotoxin and it is used for the CTCL therapy. DAB389IL-2 includes of two distinct portions; the catalytic domain of diphtheria toxin and IL-2. DAB389IL-2 duo to the presence of a free cysteine residue (Cys
Nasrin Zarkar, Mohammad Ali Nasiri Khalili, Sirus Khodadadi, Mehdi Zeinoddini, Maryam Ghodrati Siahmazgi, Nasrin Faramarzi   +5 more
doaj  

Melanin Nanoparticles as a Safe and Effective Iron Chelation Therapy: An ex vivo Assessment of Placental Transfer in Pregnant Beta-Thalassemia

International Journal of Nanomedicine
Nahla Bakhamis,1 Toluwalase Awoyemi,1 Manu Vatish,1 Helen Townley1,2 1Nuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, UK; 2Department of Engineering Science, University of Oxford, Oxford, UKCorrespondence ...
Bakhamis N, Awoyemi T, Vatish M, Townley H   +3 more
doaj  

Solvent Reorganization in Stabilized Protein-Polymer Conjugates Visualized by Two-Dimensional Infrared and Nuclear Magnetic Resonance Spectroscopy. [PDF]

JACS Au
Maia R, Chen X, Mulry E, Eddy MT, Baiz CR.   +4 more
europepmc   +1 more source

Cysteine Pegylation of a Mutant L-asparaginase Affords Enhanced Activity and Thermostability. A Comparative Study Against N-terminal Conjugation. [PDF]

Appl Biochem Biotechnol
Ferraro RB, Benevides GR, Rabelo J, da Silva Chaves F, Ruiz-Lara GV, Carretero G, Monteiro G, Pessoa-Junior A, Converti A, Lynham S, Long PF, Rangel-Yagui CO.   +11 more
europepmc   +1 more source

Site-Specific PEGylation at Residue 86 Improves Pharmacokinetic Properties of Interferon α-2b. [PDF]

Iran J Biotechnol
Alboshokeh MA, Mirshekar S, Hedayati MH, Gholami A, Javdani Shahedin G, Arabi Mianroodi R.   +5 more
europepmc   +1 more source

Site- and Size-Controlled PEGylation Modulates Biointerfaces and Immunoregulatory Functions of Bifunctional Peptides in an Autoimmune Disease Model. [PDF]

ACS Appl Mater Interfaces
Song SJ, Villela Nava AL, Xie J, Li X, Siahaan TJ, Kim H.   +5 more
europepmc   +1 more source

Mechanistic Insights Into the Retention and Separation Mechanism of Poly(Ethylene Glycol)-Modified Short Oligonucleotides in Anion-Exchange Chromatography. [PDF]

Biotechnol J
Yoshimoto N, Matsumoto T, Ono Y, Kumagai Y.   +3 more
europepmc   +1 more source