Results 201 to 210 of about 373,225 (307)

Targeting Macrophage STING O‐GlcNAcylation via Small‐Molecule Allosteric Modulation for Psoriasis Therapy

open access: yesAdvanced Science, EarlyView.
Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo   +10 more
wiley   +1 more source

Interfacial Reconstruction Enables Enhanced Thermoelectric Performance in Bismuth Telluride‐Based Alloys

open access: yesAdvanced Science, EarlyView.
Bismuth telluride‐based alloys are benchmark thermoelectric materials for near‐room‐temperature applications. Here, SnSe‐induced interfacial reconstruction simultaneously optimizes carrier and phonon transport in Bi0.4Sb1.6Te3, achieving a peak ZT of ∼1.38 at 363 K and a device efficiency of ∼6.47%, providing an effective strategy for high‐performance ...
Wenyi Chen   +11 more
wiley   +1 more source

Optimization of PEI-mediated transient transfection for antibody production in Expi293F cells by iron ion supplementation. [PDF]

open access: yesBiochem Biophys Rep
Liu Y   +8 more
europepmc   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang   +10 more
wiley   +1 more source

Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium

open access: yesAdvanced Science, EarlyView.
Pediatric acute respiratory distress syndrome (PARDS) suppresses the FOXF1 transcription factor and disrupts lung development. This study shows that the FOXF1‐activating small‐molecule compound, TanFe[F], can be precisely delivered to lung endothelial cells using the innovative LEDD nanoparticle system.
Afzaal N. Mohammed   +12 more
wiley   +1 more source

Saponin conjugation improves p-CRISPR delivery by polyethylenimine modified carbon dots. [PDF]

open access: yesBioimpacts
Kelkawi AHA   +10 more
europepmc   +1 more source

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