Results 211 to 220 of about 373,225 (307)

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

A Fluorogenic Cysteine‐Tetrapeptide Tagging Strategy for Nonperturbative Protein Labeling and Protein–Ligand Interaction Tracking

Advanced Science, EarlyView.
A compact Phe‐Cys‐Pro‐Phe (FCPF) tag and an environment‐sensitive SBD‐Cl‐derived probe form a sequence‐selective fluorogenic pair for wash‐free live‐cell protein imaging. This minimally perturbing chemistry allows flexible insertion at termini or loops, produces strong fluorescence upon local microenvironment confinement, supports FRET‐assisted ...
Xiao Wang, Xingcan Pan, Yongling Ying, Ziqian Bai, Jingming Zhang, Zhuang Shao, Jialiang Qian, Hongwei Li, Ning Zhang, Fan Yang, Yuan Liu, Xing Yang   +11 more
wiley   +1 more source

Bio-Based Phenolic Aldehyde Functionalization of Cellulose Acetate-Polyethyleneimine Membranes for Enhanced Ni²⁺ and Cu²⁺ Retention. [PDF]

Polymers (Basel)
Piscanu EI, Damian CM, Pandele AM, Oprea M, Nicoara AI, Voicu SI.   +5 more
europepmc   +1 more source

Dramatic Enhancement and Integration of Properties in Pork Belly‐Inspired All‐Biomass Composite Films via Facile, Sustainable, and Controllable Design

Advanced Science, EarlyView.
A pork belly‐inspired all‐biomass composite film was constructed through layer‐by‐layer assembly of cellulose nanofibers (CNFs), gelatin, and graphitized carbon nanosheets (GCNs) via hydrogen bonding and π–π stacking interactions. The excellent mechanical properties, effective thermal management, and outstanding EMI shielding performance of the ...
Junchao Ren, Chenglei Huang, Chengxu Pei, Mengde Huang, Yuanyuan Xu, Chengyu Yu, Hao Nie, Guangbing Zhao, Shijing Song, Hanwu Lei, Fang Wang, Bin Li, Qingfa Zhang   +12 more
wiley   +1 more source

Polyethylenimine/Graphene Oxide Nanocomposite for Lightweight X-Ray Radiation Shielding in Aerospace Applications. [PDF]

Materials (Basel)
Botti S, Bonfigli F, Rondino F, Hampai D, Cherepennikov Y, Dabagov S.   +5 more
europepmc   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

Erratum to: S-palmitoylation of MTDH regulates ferroptosis resistance in breast cancer cell [Journal Lipid Research 67/1 (2026) 100953]. [PDF]

J Lipid Res
Pei S, Wang W, Feng T, Wang Q, Wang Y, Liu HX, Liang X, Piao HL.   +7 more
europepmc   +1 more source

Phosphate‐Engineered DNA Reporters Boost CRISPR‐Cas12a Trans‐Cleavage for Rapid and Sensitive Nucleic Acid Detection

Advanced Science, EarlyView.
We uncover dual CRISPR‐Cas12a trans‐cleavage activities: endonucleolytic cleavage and 3′→5′ exonucleolytic trimming of ssDNA reporters. Mechanism‐guided 3′‐phosphate engineering accelerates substrate cleavage while favoring endonucleolytic processing, enabling Phos‐CRISPR, a rapid (20 min), highly sensitive, and specific platform for nucleic acid ...
Rui Yang, Chong Guo, Minjie Pei, Jiongyu Zhang, Xin Guan, Shuo Zhang, Xingye Liu, Kurt T. Schalper, Lori Avery, Rocco LaSala, David Banach, Changchun Liu   +11 more
wiley   +1 more source

Dual-doped all-graphene fiber for flexible, high-performance thermoelectric temperature sensing. [PDF]

Microsyst Nanoeng
Han F, Zhong Q, Du J, Hu J, An P, Zhao Y, Zheng K, Wang S, Zhang Y, Lu D, Wang C, Jiao B, Jiang Z.   +12 more
europepmc   +1 more source

Reln mRNA Delivery Drives Neurogenic Bone Regeneration by Orchestrating Schwann Cell‐Mediated Exosomal Trafficking

Advanced Science, EarlyView.
MSNs serve as a robust vehicle for CRISPRa‐mediated Reln induction, driving bone repair through the establishment of a neurogenic‐supportive microenvironment. ABSTRACT Neurogenic bone regeneration is essential for the effective restoration of bone tissue functionality, while the mechanisms and new strategies underlying neurogenic bone regeneration ...
Shuai Lin, Qianwen Li, Duo Liu, Mingzhao Li, Han Zhang, Liujing Chen, Yan Yu, Jiuhui Jiang, Chun Xu, Ruili Yang   +9 more
wiley   +1 more source