Results 91 to 100 of about 586,078 (308)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Analytical Model of Neutral Gas Shielding for Hydrogen Pellet Ablation

, 2001
"A kinetic gasdynamic scaling for hydrogen pellet ablation is obtained in terms of a neutral gas shielding model using both numerical and analytical approaches.
"Kuteev, V. Boris, Tsendin, Lev D."
core  

Exploiting flavour preferences of common marmosets to increase palatability of a dry pellet diet [PDF]

, 2009
Although commercially available complete diets exist for common marmosets, the animals’ consumption of these diets (available in dry pellet form) is typically very low.
Watson, Claire F I, Morris, Keith, Caldwell, Christine Anna   +2 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A Pellet Fűtési Alapú Felhasználása a Nyíregyházi Távhőszolgáltatásban

, 2011
Szakdolgozat (Szakács Balázs) MESZ - A Pellet Fűtési Alapú Felhasználása a Nyíregyházi TávhőszolgáltatásbangjMegújuló Energetikai Szakértő képzés (MESZ)régi ...
Szakács, Balázs
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Production and launch studies of cryogenic pellets for the ITER disruption mitigation system

Nuclear Fusion
A support laboratory has been set up to study pellet production, launch and shattering of cryogenic protium, deuterium, and neon pellets for the ITER disruption mitigation system, which plans to use 28.5 × 57 mm (diameter × length) protium, neon an ...
Sándor Zoletnik, Gergely Bartók, Attila Buzás, Gábor Cseh, Dániel Dunai, Gábor Gárdonyi, Sándor Hegedűs, Gábor Kocsis, Marcell Málics, Domonkos Nagy, Dániel Imre Réfy, Tamás Szabolics, Tamás Szepesi, Márton Vavrik, Miklós Vécsei, Erik Walcz, Stefan Jachmich, Uron Kruezi, Michael Lehnen   +18 more
doaj   +1 more source

Particle size and wettability effect of ultrafine magnetite concentrate on ballability

工程科学学报, 2017
Two kinds of magnetite concentrates from Pilbara in Australia and an area in the northeast in China were used to explore the effect of wettability, which depends on particle size, on ballability.
PAN Jian, TIAN Hong-yu, ZHU De-qing, YANG Cong-cong, XU Meng-jie   +4 more
doaj   +1 more source