Results 31 to 40 of about 1,715,491 (270)

CDK12-Mediated Phosphorylation of FOXA1 Promotes Prostate Cancer Progression via the MDM2–p53 Axis

Research
Prostate cancer (PCa) progression is driven by intricate molecular mechanisms involving dysregulated signaling networks and posttranslational modifications of key regulatory proteins.
Binyuan Yan, Mengjun Huang, Jinxiang Wang, Hanqi Lei, Tongyu Tong, Bin Xu, Fei Cao, Qiliang Teng, Jinsheng Huang, Yupeng Guan, Wenjun Mao, Haojie Huang, Jun Pang   +12 more
doaj   +1 more source

One in five women suffer from pelvic floor disorders in Kersa district Eastern Ethiopia: a community-based study

BMC Women's Health, 2018
Background Hundreds of millions of women suffer from pelvic floor disorders globally, often in silence. Women in developing countries do not disclose their problems due to associated social stigma or lack of access to services.
Merga Dheresa, Alemayehu Worku, Lemessa Oljira, Bizatu Mengiste, Nega Assefa, Yemane Berhane   +5 more
doaj   +1 more source

[Pelvic floor muscle training and pelvic floor disorders in women].

Gynecologie, obstetrique & fertilite, 2015
Our goal is to provide an update on the results of pelvic floor rehabilitation in the treatment of urinary incontinence and genital prolapse symptoms.Pelvic floor muscle training allows a reduction of urinary incontinence symptoms. Pelvic floor muscle contractions supervised by a healthcare professional allow cure in half cases of stress urinary ...
Thubert, Thibault, Bakker, Els, Fritel, Xavier   +2 more
openaire   +2 more sources

Long-term effects and costs of pelvic floor muscle training for prolapse: trial follow-up record-linkage study [PDF]

, 2022
Introduction: Pelvic organ prolapse affects around 40% of women aged over 50 years. A multicentre parallel group randomised trial (the Pelvic Organ Prolapse PhysiotherapY (POPPY) trial) demonstrated pelvic floor muscle training (PFMT) was effective in ...
Mason, Helen, Hagen, Suzanne, Hagen, Suzanne; id_orcid, Fenocchi, Linda, Elders, Andrew, Maxwell, Margaret, Fenocchi, Linda; id_orcid, Best, Catherine   +7 more
core   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Frontier knowledge and future directions of programmed cell death in clear cell renal cell carcinoma

Cell Death Discovery
Clear cell renal cell carcinoma (ccRCC) is one of the most common renal malignancies of the urinary system. Patient outcomes are relatively poor due to the lack of early diagnostic markers and resistance to existing treatment options.
Cao Fei, Xu Zhen, Zhang Shiqiang, Pang Jun   +3 more
doaj   +1 more source

Pelvic floor dysfunction: prevalence and associated factors

BMC Public Health, 2023
Background Pelvic floor dysfunction in women encompasses a wide range of clinical disorders: urinary incontinence, pelvic organ prolapse, fecal incontinence, and pelvic-perineal region pain syndrome.
Rocío Adriana Peinado-Molina, Antonio Hernández-Martínez, Sergio Martínez-Vázquez, Julián Rodríguez-Almagro, Juan Miguel Martínez-Galiano   +4 more
doaj   +1 more source

Obesity and Pelvic Floor Disorders [PDF]

Obstetrics & Gynecology, 2008
To review the current literature and summarize the effect of obesity on outcomes of surgical treatment of pelvic floor disorders as well as the effect of weight loss on pelvic floor disorder symptoms.Relevant sources were identified by a MEDLINE search from 1966 to 2007 using the key words obesity, pelvic floor disorders, urinary incontinence (UI ...
W Jerod, Greer, Holly E, Richter, Alfred A, Bartolucci, Kathryn L, Burgio   +3 more
openaire   +2 more sources

Soft Robotic Excretory Care Simulator for Nursing Education: Functional and Perceptual Biomimetics Approach

Advanced Robotics Research, EarlyView.
A soft robotic simulator is developed to replicate the digital removal of feces (DRF), a sensitive yet essential nursing procedure. Integrating soft actuators, sensors, and a realistic rectal model, the simulator balances functional fidelity with perceptual realism. Engineering evaluations and nurse feedback confirm its potential to enhance training in
Shoko Miyagawa, Sota Suzuki, Shizuka Watanabe, Zebing Mao, Young Ah Seong, Toshinori Fujie, Tatsuhiro Horii, Kenjiro Tadakuma, Koichi Suzumori, Hiroyuki Nabae, Shingo Maeda   +10 more
wiley   +1 more source

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

The Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson, Pierre Frémondière, Kaspar Staub, Philipp Mitteroecker, Barbara Fischer, Martin Haeusler, Nicole M. Webb   +6 more
wiley   +1 more source