Results 41 to 50 of about 16,979 (240)

Targeting YAP1-CD70 axis potentiates the efficacy of anti-PD-1 therapy in prostate cancer

Biomarker Research
The mechanisms by which prostate cancer (PCa) evades anti-tumor immunity and the immune checkpoint blockade (ICB) response are poorly understood. Yes-associated protein 1 (YAP1) activation is a common feature in PCa.
Tongyu Tong, Yupeng Guan, Juan Luo, Binyuan Yan, Xiangwei Yang, Junfu Zhang, Zheng Yang, Fei Cao, Guangxi Sun, Hao Zeng, Peng Li, Jun Pang   +11 more
doaj   +1 more source

Frequency of pelvic floor disorders and related socio-demographic and obstetric determinants in reproductive aged women in Tabriz city, 2021-2022 [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Pelvic floor disorders are one of the most common morbidities in women, which have negative consequences on women's daily life. Since the total prevalence of this disorder among Iranian′s women has not been reported by appropriate tools ...
Fatemeh Rashidi, Mojgan Mirghafourvand
doaj   +1 more source

Creation and Implementation of Virtual Urogynecology Patient Cases for Medical Student Education

MedEdPORTAL, 2022
Introduction Urogynecologic disorders are highly prevalent, and many physicians across various specialties will encounter and care for patients with pelvic floor disorders.
Jacqueline Y. Kikuchi, Margot Le Neveu, Shannon Arnold, Austin Offnick, Keila S. Muñiz, Prerna Pandya, Rehan Feroz, Jaime B. Long, Lindsay R. Ledebur, Danielle Patterson, Chi Chiung Grace Chen   +10 more
doaj   +1 more source

Minimalist Footwear Acutely Alters Running Kinematics in Runners With Medial Tibial Stress Syndrome

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess immediate biomechanical changes in runners with medial tibial stress syndrome (MTSS) when transitioning from standard to minimalist running shoes. Methods Active runners diagnosed with MTSS ran on a treadmill at 10 km/h using standard and minimalist running shoes. Hip, knee, and ankle joint kinematics were captured using a 16‐infrared‐
Quyet Thang Nguyen, My T. Than, Minh Ho Ngoc, Ngoc‐Tram Nguyen, Nam Vu Tu, Tien Quang Tran, Dung Tran Trung   +6 more
wiley   +1 more source

Essential embryology for the Canadian pathologists’ assistant

Anatomical Sciences Education, EarlyView.
Abstract Pathologists' assistants (PAs) are pivotal in healthcare, conducting autopsies and examining tissues under a pathologist's guidance. Embryology knowledge is crucial for PAs to accurately assess anomalies and identify pathologies. Yet, it is often overlooked in academic PA training programs.
Samantha H. Nacci, William Tsui, Fang‐I Lu, Avrum I. Gotlieb, Danielle C. Bentley   +4 more
wiley   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Grooved Surface of the Obturator Internus Muscle With Two Distinct Adjacent Parts

Clinical Anatomy, EarlyView.
ABSTRACT The specific anatomical features of the obturator internus, particularly those of its medial surface, remain insufficiently characterized. This study investigated the morphology of the obturator internus muscle by focusing on the shape of its medial surface and potential age‐related changes.
Satoru Muro, Junichi Tsuchiya, Takuya Ibara, Akimoto Nimura, Keiichi Akita   +4 more
wiley   +1 more source

Associations of cigarette use, e-cigarette use, and dual use, with nocturia and urge urinary incontinence in US adults

Tobacco Induced Diseases
Introduction Associations of cigarette use, e-cigarette use, and dual use, with nocturia and urge urinary incontinence (UUI) remain unclear. We performed this study to investigate the associations of cigarette use, e-cigarette use, and dual use, with ...
Xiangwei Yang, Yuhang Xie, Hong Chen, Junfu Zhang, Wenhan Qiu, Jun Pang   +5 more
doaj   +1 more source

Obstetrics and gynecology devices designed for low‐ and middle‐income countries: A narrative review

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 71-80, April 2025.
Abstract There are many barriers contributing to poor health outcomes for women in low‐ and middle‐income countries (LMICs), one of which is the lack of necessary medical devices. Presently, the development of various kinds of devices intended to improve women's health outcomes specifically in LMICs remains underrepresented in the literature; therefore,
Dhanalakshmi Thiyagarajan, Enaam A. Adanu, K. Rivet Amico   +2 more
wiley   +1 more source

Novel mRNA adjuvant ImmunER enhances prostate cancer tumor-associated antigen mRNA therapy via augmenting T cell activity

OncoImmunology
Prostate cancer (PCa) is characterized as a “cold tumor” with limited immune responses, rendering the tumor resistant to immune checkpoint inhibitors (ICI).
Zhen Xu, Ze-Xiu Xiao, Jing Wang, Hao-Wei Qiu, Fei Cao, Shi-Qiang Zhang, Yuan-Dong Xu, Han-Qi Lei, Heng Xia, Yun-Ru He, Gao-Feng Zha, Jun Pang   +11 more
doaj   +1 more source