Results 201 to 210 of about 160,542 (279)

Broader gene representation by whole-exome sequencing improves accuracy of tumor mutational burden assessment for selection of pembrolizumab immunotherapy. [PDF]

Cancer Immunol Immunother
Radovich M, Wacker J, Solzak J, Tae H, Ribeiro JR, Maney T, Hancock B, Hamrick J, Sledge GW, Ahluwalia MS, Liu SV, Lou E, Subbiah V, Halmos B, Magee D, Spetzler DB.   +15 more
europepmc   +1 more source

Cardiac surveillance in immune checkpoint inhibitor therapy: Insights from the Essen Cardio‐oncology Registry

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia, Lisa Zimmer, Lena Lampe, Dimitra Vlachopoulou, Matthias Totzeck, Tienush Rassaf, Raluca I. Mincu   +6 more
wiley   +1 more source

Axitinib-Pembrolizumab and Adverse Event Management in Patients With Advanced Renal Cell Carcinoma.

JAMA Netw Open
Shah NJ, Ababio Y, Eccleston A, Rao D, Kelly SP, Chang J, Lucht S, Paydar C, Van Doren BA, Bland E, John W, Giegerich S, Laney J, Feinberg B, Zarrabi KK.   +14 more
europepmc   +1 more source

Real-world outcomes of pembrolizumab in advanced anal cancer: a nationwide Danish anal Cancer Group report. [PDF]

Acta Oncol
Garm Spindler KL, Hvid CA, Fokdal LU, Wind KL, Jakobsen AV, Eefsen RL, Serup-Hansen E.   +6 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

FDA Approval Summary: Pembrolizumab for the Treatment of HER2-Positive Gastric Cancer. [PDF]

Clin Cancer Res
Casak SJ, Zhang Y, Song C, Mishra-Kalyani PS, Tang S, Auth D, de Claro RA, Pazdur R, Lemery SJ.   +8 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Case Report: Two atypical cases of M6-like antimitochondrial antibody pattern unlinked to iproniazid. [PDF]

Front Immunol
Tolmer E, Bonnet B, Jeannin G, Junda M, Godignon M, Evrard B.   +5 more
europepmc   +1 more source

Dupilumab as an Effective Adjuvant Therapy for Corticosteroid‐Refractory Lichenoid‐Bullous Dermatitis Secondary to Pembrolizumab

Australasian Journal of Dermatology, EarlyView.
Brandon Tan, Gaurav N. Pathak, Alexis Lara Rivero   +2 more
wiley   +1 more source

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

British Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen, Ines Bentahrour, Camille Guerin, Charles Dolladille, Angélique Da Silva, François Cherifi, Elise‐Marie Minoc, Pierre‐Marie Morice, Nicolas Jacquin, Christophe Le Tourneau, Joachim Alexandre, Ahmad Nehme, Etienne Bastien   +12 more
wiley   +1 more source