Histopathological Aspects of Common Immune Checkpoint Inhibitors Induced Skin Toxicities
ABSTRACT Background The histological characteristics of checkpoint inhibitors‐related adverse events (cirAEs) are not well studied and there are conflicting data regarding their similarities and differences with their idiopathic counterparts. Objectives To investigate the histological characteristics of the most common cirAEs.
Christina Kemanetzi +12 more
wiley +1 more source
Surgical management of concomitant ptosis and cicatricial entropion in a patient with ocular cicatricial pemphigoid [PDF]
Purpose: To report on the surgical management of concurrent ptosis and entropion in a patient with cicatricial pemphigoid. Case report: A 71 year-old patient presented with vision impairment and pain in the right eye due to entropion associated ...
Lambiase, Alessandro +3 more
core +1 more source
Whole-genome expression Profiling in skin reveals sYK as a Key regulator of inflammation in experimental epidermolysis Bullosa acquisita [PDF]
Because of the morbidity and limited therapeutic options of autoimmune diseases, there is a high, and thus far, unmet medical need for development of novel treatments.
Aga +57 more
core +6 more sources
Proteases in Pemphigoid Diseases
Pemphigoid diseases are a subgroup of autoimmune skin diseases characterized by widespread tense blisters. Standard of care typically involves immunosuppressive treatments, which may be insufficient and are often associated with significant adverse ...
Sho Hiroyasu +11 more
doaj +1 more source
Paraneoplastic pemphigus: insight into the autoimmune pathogenesis, clinical features and therapy [PDF]
Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients.
Andrea Ciofalo +21 more
core +2 more sources
Response to Oral Dapsone in a Patient With Generalised Junctional Epidermolysis Bullosa
ABSTRACT Dapsone is a potent antibacterial agent used as a first‐line treatment for leprosy and employed also as an anti‐inflammatory agent. Additionally, dapsone is used for a variety of other cutaneous conditions. Herein, we report a case of intermediate junctional epidermolysis bullosa that improved significantly with oral 4,4’‐diamino‐diphenyl ...
Shiho Mori +2 more
wiley +1 more source
A case of porphyria cutanea tarda in the setting of hepatitis C infection and tobacco usage [PDF]
Porphyria cutanea tarda (PCT) is the most common type of porphyria, presenting in middle-aged patients with a photodistributed vesiculobullous eruption, milia, and scars.
Brinster, NK +4 more
core
Limbal stem cell transplantation: clinical results, limits, and perspectives [PDF]
Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium.
Bruscolini, Alice +3 more
core +1 more source
Pemphigoid gestationis: clinical and laboratory evaluation
INTRODUCTION: Pemphigoid gestationis, also known as herpes gestationis, is a rare autoimmune blistering disease associated with pregnancy. It usually occurs during the second or third trimester, but it may be present at any stage of pregnancy or the ...
Marina Flangini Cobo +3 more
doaj +1 more source
Background: Autoimmune blistering disorders (AIBDs) are rare, potentially life-threatening conditions often requiring immunosuppression. Throughout the SARS-CoV-2 pandemic, infection risk and mortality in patients with AIBDs are unknown.
Kimberly F. Breglio, MD, DPhil +3 more
doaj +1 more source

