Results 111 to 120 of about 802,819 (312)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tissue location of resistance in apple to the rosy apple aphid established by electrical penetration graphs [PDF]

, 2009
A study of the constitutive resistance of the apple cultivar Florina, Malus domestica Borkh. (Rosaceae), to the rosy apple aphid, Dysaphis plantaginea (Passerini) (Homoptera Aphididae), was performed for the first time by the electrical penetration graph
Civolani, S., Pasqualini, E., Baroni, P., PASQUALINI, EDISON, Chicca M., E. Pasqualini, Tjallingii W. F., Tjallingii, W.F., Leis M., W. F. Tjallingii, MARCHETTI, ELISA, LEIS, Marilena, CHICCA, Milvia, P. Baronio, Chicca, M., BARONIO, PIERO, CIVOLANI, STEFANO, Leis, M., E. Marchetti, Marchetti, E.   +19 more
core  

Penetration Characteristics of Mono-Column Composite Bucket Foundation for Offshore Wind Turbines

Journal of Marine Science and Engineering
To address the issue of seepage and soil plugging during the sinking of mono-column composite bucket foundations (MCCBFs), experiments were conducted on the installation of foundations under a variety of complex geological conditions.
Jiandong Xiao, Xiaoqiang Gu, Yifeng Lin, Haifeng Cheng, Xin Qi, Puyang Zhang, Shuyang Wang   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Variable rate of penetration and dissipation test results in a natural silty soil [PDF]

, 2018
Variable rate of penetration over 1.2 to 1.5 m intervals were carried out in a natural clayey silt followed by dissipation tests. The tests are grouped into two main sets: an upper set from 5 to 6.5 m and a deeper set from 8.5 to 10.2 m.
Paniagua Lopez, Ana Priscilla, Carroll, Roselyn   +1 more
core  

Effect of piezocone penetration rate on the classification of Norweian silt [PDF]

, 2018
Interpretation of Cone Penetration Tests (CPTU) in intermediate soils is complex due to partially drained conditions during penetration. In order to gain more insight into the material behavior of silt during a CPTU, an intensive test program was carried
Long, Michael, Bihs, Annika, Gylland, Anders Samstad, Paniagua Lopez, Ana Priscilla, Nordal, Steinar   +4 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

ETHYL SILICATES WITH DIFFERENT HYDROLYSIS DEGREE LIKE NON-FLAMMABLE IMPREGNATING MATERIAL FOR WOOD SILICATOS DE ETILO CON DIFERENTE GRADO DE HIDRÓLISIS COMO MATERIAL IMPREGNANTE IGNÍFUGO PARA MADERAS

Maderas: Ciencia y Tecnología, 2008
The wood, like other materials, cannot indefinitely resist the action of the fire without undergoing deterioration. In this work, low-density wood panels were impregnated with partially hydrolyzed ethyl silicates The results obtained in laboratory, with ...
Andrea M Pereyra, Carlos A Giudice
doaj