Results 41 to 50 of about 142,438 (266)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Magnetic Field Penetration Depth in Various Materials and Applications

Applied Sciences
The magnetic field penetration depth poses challenges in communications, geophysical exploration, biomedical therapies, and superconducting device design.
Papa Pio Ascona García, Guido Elar Ordoñez Carpio, Wilmer Moisés Zelada Zamora, Edwaldo Villanueva Pedraza, Roger Alvaro Fernandez Villarroel   +4 more
doaj   +1 more source

Micro-CT assessment of sealant penetration in different types of fissures in primary molars [PDF]

Folia Medica
Introduction: Sealants prevent the development of dental caries by forming a protective barrier that reduces bacterial growth and food retention. The morphology of the pits and fissures and the material of the sealant can affect the depth to which it ...
Krasimir Hristov, Ralitsa Bogovska-Gigova, Nedana Georgieva   +2 more
doaj   +3 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Estimation of Penetration Depth Using Acceleration Signal Analysis for Underwater Free Fall Cone Penetration Tester

한국해양공학회지, 2020
A track-type underwater construction robot (URI-R) was developed by the Korea Institute of Ocean Science & Technology. Because URI-R uses tracks to move on the seabed, insufficient ground strength may hinder its movement. For smooth operation of URI-R on
Jung-min Seo, Changjoo Shin, OSoon Kwon, In Sung Jang, Hyoun Kang, Sung Gyu Won   +5 more
doaj   +1 more source

Evaluation of Penetration Depth of Sodium Hypochlorite Into Dentinal Tubules After Passive Ultrasonic Irrigation Compared to Er;Yag Laser Activation. An In-Vitro Study

Cumhuriyet Dental Journal, 2020
Objectives: The aim of this study was to compare penetration depth of sodium hypochlorite into dentinal tubules after passive ultrasonic agitation or ER; YAG activated irrigant.Materials and Methods: Twenty-four single rooted human mature mandibular ...
Salma Al Nesser, Khetam Almarrawı, Abdullah Raies   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source