Results 111 to 120 of about 853,266 (286)

Kajian Nilai Daya Dukung Tanah Dasar Menggunakan Dynamic Cone Penetrometer dan Cbr In Place [PDF]

open access: yes, 2015
In road construction, there is a need to assess the adequacy of the subgrade to behave satisfactorily beneath a pavement. The adequacy usually representated as California Bearing Ratio (CBR) value.
Azwarman, A. (Azwarman)
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Datasets of various geotechnical surveys in several arrays in the Taipei Basin

open access: yesData in Brief
The standard penetration test (SPT), seismic cone penetration test (SCPT), and various in-situ seismic tests are commonly utilized for geotechnical site investigations.
Chih-Chieh Lu   +4 more
doaj   +1 more source

Recent flow visualization studies in the 0.3-m TCT [PDF]

open access: yes
Light beams are altered by refractive index changes; flow induced refractive index changes provide the impetus for conventional visualization techniques such as schlieren and shadowgraph.
Burner, Alpheus W.   +2 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Probe penetration test applied for evaluating shotcrete compressive strength

open access: yesRevista IBRACON de Estruturas e Materiais
This study presents a methodology for evaluating shotcrete compressive strength. Because of the high surface roughness and low thickness of the concrete layer observed in shotcrete structures, the proposed methodology is based on the probe penetration ...
W. R. L. da Silva   +2 more
doaj   +1 more source

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