Results 61 to 70 of about 853,266 (286)

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

open access: yes
Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Blade Sharpness and its Effect on the Testing of Body Armours [PDF]

open access: yes, 2002
Factors such as edge sharpness and tip sharpness have been identified by Horsfall,1 as keyvariables in the testing of stab and slash resistant armours.
Champion, Stephen M.   +3 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Application of Dynamic Cone Penetration Test to Gypseous Soils

open access: yesTikrit Journal of Engineering Sciences, 2018
Dynamic cone penetration test (DCPT) is a fast, economical and easy to conduct. It is widely used to assess the strength of natural and compacted soils. The device is introduced in the 1950s. However, it was newly introduced in Iraq.
Ahmed A. H. Al-Obaidi   +1 more
doaj   +3 more sources

Analysis of Structural Crashworthiness and Estimating Safety Limit Accounting for Ship Collisions on Strait Territory

open access: yesLatin American Journal of Solids and Structures
A series of analyses are carried out to predict the structural crashworthiness of a ship during a collision. The numerical configuration is verified by structural simulations based on a laboratory experiment wherein a penetration test is considered as ...
Aditya Rio Prabowo   +3 more
doaj   +1 more source

The cone penetration test in unsaturated silty sands

open access: yesE3S Web of Conferences, 2016
Very little is known about how to interpret the cone penetration test (CPT) when performed in unsaturated soils. The few published studies on the CPT in unsaturated soils have focused on either clean sands or a silt.
Yang Hongwei, Russell Adrian
doaj   +1 more source

Capturing Distribution Grid-Integrated Solar Variability and Uncertainty Using Microgrids

open access: yes, 2017
The variable nature of the solar generation and the inherent uncertainty in solar generation forecasts are two challenging issues for utility grids, especially as the distribution grid integrated solar generation proliferates.
Bahramirad, Shay   +2 more
core   +1 more source

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