Results 71 to 80 of about 853,266 (286)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Rheology, permeability and microstructure of seawater-based slurry for slurry shield tunneling: insights from laboratory tests

Frontiers in Materials
During slurry shield tunneling in submarine geological conditions, it is of significance to prepare an appropriate slurry to maintain excellent rheological properties and penetration characteristics.
Junqi Ru, Yingran Fang, Yingran Fang, Yidong Guo, Yidong Guo, Luqing Jiang, Hongzhi Liu, Xinggao Li, Xinggao Li, Weiqiang Qi   +9 more
doaj   +1 more source

Import Penetration, Intermediate Inputs and Productivity: Evidence from Italian Firms [PDF]

We test the impact of import penetration on the productivity of a sample of roughly 35,000 Italian manufacturing firms operating in the period 1996-2003, considering the impact on productivity of both import penetration in the same industry and import ...
Altomonte, Carlo, Barattieri, Alessandro, Rungi, Armando   +2 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Developing a Regionally Adaptable CPT-SPT Correlation Using Linear Regression and Genetic Algorithms

Applied Sciences
Establishing a correlation between the Cone Penetration Test (CPT) and the Standard Penetration Test (SPT) is of significant importance for geotechnical engineering practice. A novel correlation between CPT-qt and SPT-N60 based on a genetic algorithm (GA)
Shuai Fang, Nan Zhang, Xinpeng Lv, Haoran Li   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Model for initiation of quality factor degradation at high accelerating fields in superconducting radio-frequency cavities

, 2010
A model for the onset of the reduction in SRF cavity quality factor, the so-called Q-drop, at high accelerating electric fields is presented. Breakdown of the surface barrier against magnetic flux penetration at the cavity equator is considered to be the
A Dzyuba, A Romanenko, Berry S Antoine C Desmons M, Ciovati G, Eremeev G, Ge M Wu G Burk D Hicks D Thompson C Cooley L D, Ginsburg C, Knobloch J Geng R L Liepe M Padamsee H, L D Cooley, Lilje L Reschke D, Padamsee H, Ribell G, Romanenko A, Romanenko A, Saito K, Shemelin V Padamsee H, Tian H, Tian H Sommer W Trofimova O Reece C E Zhao L, Valles N R A, Valles N R A Liepe M, Visentin B, Visentin B Barthe M F Desgardin P Moineau V, Watanabe K   +22 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source