Results 31 to 40 of about 4,762 (258)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

ESTUDO EXPERIMENTAL DAS RELAÇÕES TECLDUAIS EM RATOS, PROVOCADAS POR DIFERENTES CONCENTRAÇÕES DE PENICILINA G. BENZATINA

Revista da Escola de Enfermagem da USP
A procura de respostas científicas aos problemas decorrentes de procedimentos que envolvem ações profissionais constituem um desafio constante aos enfermeiros comprometidos com a melhoria do cuidado de enfermagem.
Mara Rita Rodrigues Massad, Eduardo Massad, Edna Apparecida Moura Arcuri   +2 more
doaj   +1 more source

The effect of a large dose of intravenous immunoglobulin on general paresis of the insane

European Journal of Inflammation, 2021
General paresis of the insane (GPI) remains the form of neurosyphilis most closely associated with dementia, even after the advent of penicillin. Penicillin remains the top treatment choice for syphilis, but treatment failure is not rare.
Chen Qingqing MD, Liu Dongliang MD, Sang Qingqing MD, Sang Daoqian MD   +3 more
doaj   +1 more source

Resistensi Antibiotik terhadap Bakteri Escherichia coli yang Diisolasi dari Ayam Layer di Desa Sesaot Kabupaten Lombok Barat

Media Kedokteran Hewan, 2022
Resistensi antibiotik saat ini menjadi ancaman terbesar bagi kesehatan masyarakat global, sehingga WHO mengkoordinasi kampanye global untuk meningkatkan kesadaran masyarakat terhadap antibiotik.
Alfiana Laili Dwi Agustin, Novarina Sulsia Ista'In Ningtyas, Kunti Tirtasari   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Efficiency Evalution Ultrasonic/Fenton Process in Removal of Antibiotic Penicillin G from Aquatic Solution by Response Surface Methodology

Muhandisī-i Bihdāsht-i Muḥīṭ, 2017
Background and Purpose: Extreme use of antibiotics and discharging them to the environment lead to serious consequences. Antibiotic Penicillin G a common antibiotic due to high production and are used in the treatment of infectious diseases  health ...
Ayat hossein panahi, Hossein Kamani, Fateme sancholi, Mohamad Havangi1   +3 more
doaj  

Evaluation of tetracycline, oxytetracycline and penicillin G residues in chicken meat samples by high performance liquid chromatography with pda detection

Cumhuriyet Science Journal, 2020
Penicillin G, tetracycline and oxytetracycline are broad-spectrum antibiotics with considerably low side effects which are used in most of the poultries.
Fatos Ayca Ozdemir Olgun, Birsen Demirata   +1 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

The Penicillin Derivatives as Corrosion Inhibitors for Mild Steel in Hydrochloric Acid Solution: Experimental and Theoretical Studies

International Journal of Electrochemical Science, 2015
The inhibition performances of four penicillin derivatives, including penicillin G, oxacillin, penicillin V and amoxicillin as organic corrosion inhibitors for mild steel in 1.0 M HCl solution were investigated by weight loss measurement and Tafel ...
Yi Liang, Cheng Wang, JianSheng Li, LianJun Wang, JiaJun Fu   +4 more
doaj   +1 more source