Results 71 to 80 of about 4,762 (258)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Performance Comparison of Hollow Fiber Membrane Contactors for Liquid-Liquid Extraction of Penicillin-G from Wastewater [PDF]

open access: yesمحیط زیست و مهندسی آب
Pharmaceutical waste is one of the considerable problems of the environment. Membrane contactors are used to treat various of wastewater. This study compared the effectiveness of polyvinylidene fluoride-hexafluoropropylene (PVDF-HFP) and polysulfone (PSF)
Farzaneh Abbasisourki   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

In vitro selection of mutants of Streptococcus pneumoniae resistant to macrolides and linezolid: relationship with susceptibility to penicillin G or macrolides [PDF]

open access: bronze, 2005
H. Carsenti-Dellamonica   +8 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Erratum to: Penicillin G acylase from Achromobacter sp. CCM 4824 [PDF]

open access: bronze, 2014
Stanislav Bečka   +13 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Laryngeal Actinomycosis -A Case of 36 Year Old Female at Hawassa University Comprehensive Specialized Hospital in Hawassa, Sidama, Ethiopia, Ethiopian Patient

open access: yesInternational Medical Case Reports Journal, 2022
Abebaw Amare,1 Muluken Bekele,2 Alemayehu Toma,3 Worku Ketema4 1Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Sidama, Ethiopia; 2Department of ENT, Hawassa University Comprehensive Specialized Hospital, Hawassa,
Amare A, Bekele M, Toma A, Ketema W
doaj  

Effect of irisin on the epilepsy induced by penicillin G: An electrophysiological study

open access: bronze, 2022
Yasemin Şahin Yıldız   +4 more
openalex   +1 more source

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