Results 91 to 100 of about 3,443,339 (411)

The Relationship between Antimicrobial Use and Antimicrobial Resistance in Europe [PDF]

, 2002
In Europe, antimicrobial resistance has been monitored since 1998 by the European Antimicrobial Resistance Surveillance System (EARSS). We examined the relationship between penicillin nonsusceptibility of invasive isolates of Streptococcus pneumoniae (an
Arason, Austin, Branthwaite, Buchholz, Cars, Commissie Richtlijnen Gevoeligheidsbepalingen, Contopoulos-Ionnides, Deeks, Deutsches Institut für Normung, Fridkin, Goettsch, Goettsch, González, Irene K. Veldhuijzen, Jacob L. Kool, John E. Degener, Kristinsson, Lyytikainen, Marc J.W. Sprenger, Melander, Mouton, Mölstad, Nava, Otto Cars, Seppala, Sigvard Mölstad, Stef L.A.M. Bronzwaer, Stephenson, Tan, Udo Buchholz, Wim Goettsch   +30 more
core   +2 more sources

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, Volume 19, Issue 5, Page 1471-1492, May 2025.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Antibiotic resistance of Staphylococcus aureus isolated from the oral cavity of paraguayan participants from Coronel Oviedo, year 2021

Memorias del Instituto de Investigaciones en Ciencias de la Salud
A cross-sectional study was carried out to identify the resistance profile of Staphylococcus aureus colonizing the oral cavity of patients. Sampling was carried out with sterile swabs. Mannitol-positive colonies were cultured on blood agar, identifying S.
Ulises Villasanti Torales, Julieta Mendez, Jazmín Servin, Marylet Rodriguez, Andrea Villalba, Analia Ortiz, Pablo Franco   +6 more
doaj   +1 more source

Interdisciplinary Research-Based Learning in Organic Chemistry and Microbiology Laboratories: Synthesis and Biological Testing of Novel Penicillin Derivatives [PDF]

, 2015
Interests in the mechanism that penicillin bestows on its target protein has driven the curiosity of its binding specificity towards the methicillin resistant strain of Staphylococcus areus, and its expression of a unique penicillin binding protein that ...
Rehberger, Kyle R.
core   +1 more source

Vaginal carriage and antibiotic susceptibility profile of group B Streptococcus during late pregnancy in Ismailia, Egypt [PDF]

, 2009
SummaryGroup B Streptococcus (GBS) infection has long been recognized as a frequent cause of morbidity and mortality in newborn infants. The purpose of this study was to determine the colonization rate with GBS and the antibiotic susceptibility profile ...
Abdalla, Salah Mohamed, Abouzeid, Abouzeid M.H., Shabayek, Sarah Ahmed Abd El-kawy   +2 more
core   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model

Emerging Infectious Diseases, 2003
Streptococcus pneumoniae and Neisseria meningitidis have very similar mechanisms of resistance to penicillin G. Although penicillin resistance is now common in S. pneumoniae, it is still rare in N. meningitidis.
L. Temime, P.Y. Boëlle, P. Courvalin, D. Guillemot   +3 more
doaj   +1 more source

Nasopharyngeal S. pneumoniae carriage and density in Belgian infants after 9 years of pneumococcal conjugate vaccine programme [PDF]

, 2018
Background: In Belgium, the infant pneumococcal conjugate vaccine (PCV) programme changed from PCV7 (2007-2011) to PCV13 (2011-2015) and to PCV10 (2015-2016). A 3-year nasopharyngeal carriage study was initiated during the programme switch in 2016.
Blaizot, Stéphanie, Desmet, Stefanie, Goossens, Herman, Malhotra-Kumar, Surbhi, NPcarriage study group, the, Theeten, Heidi, Van Damme, Pierre, Van Heirstraeten, Liesbet, Van Herck, Koen, Verhaegen, Jan, Wouters, Ine   +10 more
core   +2 more sources

Temperature Dependence of Zero-Bias Resistances of a Single Resistance-Shunted Josephson Junction [PDF]

, 2003
Zero-bias resistances of a single resistance-shunted Josephson junction are calculated as a function of the temperature by means of the path-integral Monte Carlo method in case a charging energy $E_{\rm C}$ is comparable with a Josephson energy $E_{\rm J}$. The low-temperature behavior of the zero-bias resistance changes around $\alpha=R_{\rm Q}/R_{\rm
arxiv   +1 more source