Results 31 to 40 of about 2,210,070 (253)

Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae [PDF]

, 2001
BACKGROUND: The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones.
Cottagnoud, M, Entenza, JM, Taüber, MG, Moreillon, P, Cottagnoud, P, Que, YA   +5 more
core   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Spatial exploration of Streptococcus pneumoniae clonal clustering in São Paulo, Brazil

Brazilian Journal of Infectious Diseases
OBJECTIVES: To examine the spatial distribution of Streptococcus pneumoniae and its clonal patterns collected between 2002 and 2006 in São Paulo, Brazil. METHODS: As part of an observational study in São Paulo city, Brazil, S.
Amilton Mouro, Carlos Kiffer, Paula C.M Koga, Antonio M.V Monteiro, Eduardo Celso Gerbi Camargo, Antonio Carlos Campos Pignatari   +5 more
doaj   +1 more source

Antibiotic susceptibility/resistant gene profiles of Group B streptococci isolates from pregnant women in a tertiary institution in Nigeria

Journal of Clinical Sciences, 2016
Background: Penicillin is recommended as the first-line agent for intrapartum antibiotic prophylaxis (IAP). Although Group B Streptococcus (GBS) strains are generally susceptible to penicillin with only occasional resistance, they show varying resistance
Charles J Elikwu, Oyinlola O Oduyebo, Rose I Anorlu, Brigitte Konig   +3 more
doaj   +1 more source

Penicillin-resistant Variants of Pneumococci [PDF]

Applied Microbiology, 1968
All of the 74 strains of pneumococci isolated from human infections from 1963 to 1964 proved to be uniformly and highly susceptible to penicillin. Of these strains, 15 were identified by capsule-swelling reactions and were submitted to serial transfer in the presence of increasing concentrations of penicillin.
J B, Gunnison, M A, Fraher, E A, Pelcher, E, Jasetz   +3 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Penicillin-resistant and Penicillin-dependent Staphylococcal Variants [PDF]

Journal of General Microbiology, 1953
SUMMARY: Four strains of Staphylococcus aureus (coagulase-positive) were each subjected to three or more series of transfers on penicillin ditch plates. The plates were examined for colonial variants and four quite distinct types of penicillin-resistant variant, one of which was penicillin-dependent, were isolated.
openaire   +2 more sources

Threshold for Penicillin Induced Seizure in Hippocampal Slice [PDF]

, 1982
1982-11To investigate whether different types of neurons have a different threshold for seizure activity, the thresholds of two types of neurons in the hippocampal formation of a guinea pig, i.e., the CA3 cells in the hippocampus proper, and the granule ...
KAGEYAMA, NAOKI, TOSAKI, FUJIO, YUASA, HIROMI   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source