Results 41 to 50 of about 328,187 (300)

Spatial exploration of Streptococcus pneumoniae clonal clustering in São Paulo, Brazil

Brazilian Journal of Infectious Diseases
OBJECTIVES: To examine the spatial distribution of Streptococcus pneumoniae and its clonal patterns collected between 2002 and 2006 in São Paulo, Brazil. METHODS: As part of an observational study in São Paulo city, Brazil, S.
Amilton Mouro, Carlos Kiffer, Paula C.M Koga, Antonio M.V Monteiro, Eduardo Celso Gerbi Camargo, Antonio Carlos Campos Pignatari   +5 more
doaj   +1 more source

Antibiotic susceptibility/resistant gene profiles of Group B streptococci isolates from pregnant women in a tertiary institution in Nigeria

Journal of Clinical Sciences, 2016
Background: Penicillin is recommended as the first-line agent for intrapartum antibiotic prophylaxis (IAP). Although Group B Streptococcus (GBS) strains are generally susceptible to penicillin with only occasional resistance, they show varying resistance
Charles J Elikwu, Oyinlola O Oduyebo, Rose I Anorlu, Brigitte Konig   +3 more
doaj   +1 more source

An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci.

, 2004
Low-level penicillin resistance in an international Streptococcus pneumoniae serotype 19F clone emerging in Switzerland was characterized by mutations in the penicillin-binding protein PBP2x.
Hauser, Christoph, Aebi, Suzanne, Mühlemann, Kathrin   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Penicillin-resistant and Penicillin-dependent Staphylococcal Variants [PDF]

Journal of General Microbiology, 1953
SUMMARY: Four strains of Staphylococcus aureus (coagulase-positive) were each subjected to three or more series of transfers on penicillin ditch plates. The plates were examined for colonial variants and four quite distinct types of penicillin-resistant variant, one of which was penicillin-dependent, were isolated.
openaire   +2 more sources

Towards an Ontological Representation of Resistance: The Case of MRSa

, 2009
This paper addresses a family of issues surrounding the biological phenomenon of resistance and its representation in realist ontologies. Resistance terms from various existing ontologies are examined and found to be either overly narrow, inconsistent ...
Lindsay G. Cowell, Albert Goldfain, Barry Smith, Lindsay Cowell   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Study of penicillin resistance in Streptococcus pneumoniae [PDF]

, 2021
Bacterial antibiotic resistance constitutes a major and current threat worldwide and the development of new antibacterial strategies is considered a priority for organisms such as Streptococcus pneumoniae. The murMN operon in S.
Martins, Jorge Miguel Alves
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Penicillin Resistance Compromises Nod1-Dependent Proinflammatory Activity and Virulence Fitness of Neisseria meningitidis

, 2013
SummaryNeisseria meningitidis is a life-threatening human bacterial pathogen responsible for pneumonia, sepsis, and meningitis. Meningococcal strains with reduced susceptibility to penicillin G (PenI) carry a mutated penicillin-binding protein (PBP2 ...
LeBourhis, Lionel, Thouron, Françoise, Werts, Catherine, Eberl, Gérard, Taha, Muhamed-Kheir, El Ghachi, Meriem, Zarantonelli, Maria Leticia, Sansonetti, Philippe, Vives, Francina Langa, Girardin, Stephen E., Pedron, Thierry, Mulet, Céline, Peduto, Lucie, Girardin, Stephen, E., Boneca, Ivo, Gomperts, d’Andon, Martine Fanton, Skoczynska, Anna, Szatanik, Marek, Deghmane, Ala-Eddine, Nato, Faridabano, Boneca, Ivo G., Philpott, Dana J., Antignac, Aude, d'Andon, Martine Fanton, Philpott, Dana   +24 more
core   +1 more source