Results 41 to 50 of about 2,210,070 (253)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Distribution of serotypes and antimicrobial resistance of Streptococcus pneumoniae in a children's hospital in Turkey

The Turkish Journal of Pediatrics, 2004
Streptococcus pneumoniae isolates resistant to penicillin and other antibiotics have been increasing in many parts of the world. The aim of this study was to evaluate the antimicrobial susceptibilities to penicillin and other commonly used agents ...
Meral Ozalp, Güler Kanra, Deniz Gür
doaj  

Penicillin Resistance Compromises Nod1-Dependent Proinflammatory Activity and Virulence Fitness of Neisseria meningitidis [PDF]

, 2013
SummaryNeisseria meningitidis is a life-threatening human bacterial pathogen responsible for pneumonia, sepsis, and meningitis. Meningococcal strains with reduced susceptibility to penicillin G (PenI) carry a mutated penicillin-binding protein (PBP2 ...
LeBourhis, Lionel, Thouron, Françoise, Werts, Catherine, Eberl, Gérard, Taha, Muhamed-Kheir, El Ghachi, Meriem, Zarantonelli, Maria Leticia, Sansonetti, Philippe, Vives, Francina Langa, Girardin, Stephen E., Pedron, Thierry, Mulet, Céline, Peduto, Lucie, Girardin, Stephen, E., Boneca, Ivo, Gomperts, d’Andon, Martine Fanton, Skoczynska, Anna, Szatanik, Marek, Deghmane, Ala-Eddine, Nato, Faridabano, Boneca, Ivo G., Philpott, Dana J., Antignac, Aude, d'Andon, Martine Fanton, Philpott, Dana   +24 more
core   +1 more source

Pyrimidine-2-amines increase susceptibility of methicillin-resistant Staphylococcus aureus to penicillin G [PDF]

, 2022
β-lactamase (penicillinase) renders early β-lactams like penicillin G useless against methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobial discovery is difficult, and resistance exists against most treatment options.
Aurijit, Sarkar, Margaret, Deming, Payton, Thomas   +2 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Single nucleotide polymorphisms and penicillin non-susceptibility among invasive Streptococcus pneumoniae from Vietnam and India: Insights from a comparative genomics study

Journal of Global Antimicrobial Resistance
: Objectives: Streptococcus pneumoniae (S. pneumoniae) is a significant cause of global morbidity and mortality across all age groups. Antimicrobial resistance (AMR), particularly penicillin resistance, is a significant treatment challenge.
Avani Panickar, Anand Manoharan, Sudha Ramaiah   +2 more
doaj   +1 more source

Homology analysis of 51 penicillin-intermediate isolates from Wenzhou City, China

Journal of International Medical Research, 2020
Objective To investigate drug resistance features and homology among penicillin-intermediate Streptococcus pneumoniae isolates from Wenzhou City, China. Methods Fifty-one penicillin-intermediate S.
Jin Zhang, Da-Kang Hu, Chun-Yan Gao, Wei-Wei Shen, Xin-Hua Luo, Jian Yu, Xiang-Yang Li, Xin-Yu Jiang, Wu-Shuang Zhu, Wei-Qing Chen   +9 more
doaj   +1 more source

Functional analysis of four bile salt hydrolase and penicillin acylase family members in Lactobacillus plantarum WCFS1 [PDF]

, 2008
Bile salts play an important role in the digestion of lipids in vertebrates and are synthesized and conjugated to either glycine or taurine in the liver.
Lambert, J.M., Vos, W.M., de, Kleerebezem, M., Bongers, R.S., de Vos, W.M.   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source