Penicillin-resistant isolates of Neisseria-lactamica produce altered forms of penicillin-binding protein-2 that arose by interspecies horizontal gene-transfer [PDF]
, 1991 Isolates of Neisseria lactamica that have increased resistance to penicillin have emerged in recent years. Resistance to penicillin was shown to be due to the production of altered forms of penicillin-binding protein 2 (PBP 2) that have reduced affinity ...
Jones, DM +4 more
core +2 more sources
Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. [PDF]
, 2015 BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S.
Gallo, Richard L +6 more
core +3 more sources
PLoS ONE, 2014 Penicillin-binding proteins (PBPs) are enzymes responsible for the polymerization of the glycan strand and the cross-linking between glycan chains as well as the target proteins for β-lactam antibiotics.
Song Sun, M. Selmer, D. Andersson
semanticscholar +1 more source
Trends in antimicrobial resistance and serotype distribution of blood and cerebrospinal fluid isolates of streptococcus pneumoniae in South Africa, 1991–1998 [PDF]
, 2000 Objective: Since 1979, the South African Institute for Medical Research (SAIMR) has served as the national reference center for pneumococcal serotyping and monitoring of antibiotic resistance trends.
Huebner, Robin E. +2 more
core +1 more source
Three innovations of next-generation antibiotics: evolvability, specificity, and non-immunogenicity [PDF]
arXiv, 2022 Antimicrobial resistance is a silent pandemic that is being exacerbated by the uncontrolled use of antibiotics. Since the discovery of penicillin, we have been largely dependent on microbe-derived small molecules to treat bacterial infections. However, the golden era of antibiotics is coming to an end as the emergence and spread of antimicrobial ...
arxiv
Demonstration of a shift towards penicillin resistance in the Streptococcus uberis population.
Journal of Medical Microbiology, 2010 Penicillin resistance has been particularly well studied in Streptococcus pneumoniae (Denapaite et al., 2007; Hoban et al., 2005). In this organism, resistance frequently occurs through modifications of the penicillin-binding proteins (PBPs) and/or the ...
M. Haenni, E. Saras, J. Madec
semanticscholar +1 more source
The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success. [PDF]
, 2013 To access publisher´s full text version of this article. Please click on the hyperlink in Additional Links field.Streptococcus pneumoniae, also called the pneumococcus, is a major bacterial pathogen.
Beall, Bernard W +13 more
core +4 more sources
Canadian Journal of Infectious Diseases, 1992 A Canadian adult with bacteremic pneumonia caused by a relatively penicillin-resistant (minimal inhibitory concentration 0.25 μg/mL) Streptococcus pneumoniae is reported, and the published literature regarding penicillin-resistant pneumococci in Canada ...
David R Burdge +2 more
doaj +1 more source
Antimicrobial susceptibility of invasive isolates of Streptococcus pneumoniae in Ireland [PDF]
, 2004 Between January 1999 and June 2002, 646 invasive isolates of Streptococcus pneumoniae were collected in Ireland. MICs of penicillin, ciprofloxacin, cefotaxime, moxifloxacin and linezolid were determined by Etest methodology. Eighty-seven (13.5%) isolates
Clarke, P. +3 more
core +1 more source
Antibiotics, 2023 Streptococcus suis is a zoonotic pathogen causing disease in both animals and humans, and the emergence of increasingly resistant bacteria to antimicrobial agents has become a significant challenge globally. The objective of this study was to investigate
Kamonwan Lunha +5 more
doaj +1 more source