Results 31 to 40 of about 489 (168)

Antibiotic Driven Changes in Gut Motility Suggest Direct Modulation of Enteric Nervous System

Frontiers in Neuroscience, 2017
Antibiotic-mediated changes to the intestinal microbiome have largely been assumed to be the basis of antibiotic-induced neurophysiological and behavioral changes.
Thilini Delungahawatta, Thilini Delungahawatta, Jessica Y. Amin, Andrew M. Stanisz, John Bienenstock, John Bienenstock, Paul Forsythe, Paul Forsythe, Paul Forsythe, Wolfgang A. Kunze, Wolfgang A. Kunze, Wolfgang A. Kunze   +11 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Towards pharmacokinetic boosting of phenoxymethylpenicillin (penicillin-V) using probenecid for the treatment of bacterial infections

Scientific Reports
In the face of increasing antimicrobial tolerance and resistance there is a global obligation to optimise oral antimicrobial dosing strategies including narrow spectrum penicillins, such as penicillin-V.
Richard C. Wilson, Alaa Riezk, Paul Arkell, Damien Ming, Ryan Armiger, Victoria Latham, Mark J. Gilchrist, Anne-Grete Märtson, William W. Hope, Alison H. Holmes, Timothy M. Rawson   +10 more
doaj   +1 more source

Impact of narrow-spectrum penicillin V on the oral and faecal resistome in a young child treated for otitis media

Journal of Global Antimicrobial Resistance, 2020
Objectives: Antibiotic overuse has led to the global emergence of antimicrobial-resistant bacteria, and children are among the most frequent users of antibiotics.
Kjersti Sturød, Achal Dhariwal, Ulf R. Dahle, Didrik F. Vestrheim, Fernanda C. Petersen   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

ESTIMATION OF ANTIBIOTICS, SULPHONAMIDES AND NITROFURANS RESIDUES IN CHICKEN MEAT [PDF]

Assiut Veterinary Medical Journal, 1998
Fourty chicken muscle, ten liver and ten kidney samples were collected randomly from Assiut Governorate and analyzed for antibiotic, sulphonamide and nitrofuran residues.
D.A. Salem
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Efficacy and safety of 24 antibiotics for group A streptococcal pharyngitis: a network meta-analysis of 64 randomized controlled trials

Frontiers in Public Health
Background and aimsPenicillin remains the first-line therapy for group A streptococcal (GAS) pharyngitis. However, broad-spectrum antibiotics continue to be widely prescribed in clinical practice.
Xuemei Sun, Xuemei Sun, Hongya Du, Hongya Du, Yupeng Lei, Yupeng Lei, Tiechao Ruan, Tiechao Ruan, Bixin Deng, Bixin Deng, Wenting Lu, Junjie Ying, Junjie Ying, Shiping Li, Shiping Li, Ruixi Zhou, Ruixi Zhou, Dezhi Mu, Dezhi Mu   +18 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Streptococcus-associated vasculitis: A role for antibiotic therapy?

IDCases, 2021
Numerous post-Streptococcal syndromes (PSS) have been described in the literature.The role of antibiotic therapy in the management of PSS is best established with acute rheumatic fever.We present a patient with streptococcus-associated medium vessel ...
Ramy Saad, Kevin Tsoi, Ioana Anamaria Onac, Kevin A. Davies, Vijay Kumar Hajela, Cristina Tacu   +5 more
doaj   +1 more source