Results 51 to 60 of about 43,593 (360)

Conducting interviews about penile cancer: A patient-conducted-interview study [PDF]

, 2010
Objectives: Penile cancer is a rare but destructive condition. It has been found to be detrimental to body image, general health and sexual functioning, while increasing anxiety and social problems.
Branney, P, Eardley, I, Witty, K
core  

Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development. [PDF]

, 2017
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald, Isaacson, Dylan, Shen, Joel, Sinclair, Adriane, Yue, Xuan   +6 more
core   +2 more sources

Penile cancer in patient with a 'Bouglou' penile adornment [PDF]

Journal of Surgical Case Reports, 2014
Implantation of penile nodules under the foreskin aims at improving male and female sexual pleasures during intercourse. This case discusses the characteristics of the South American penile adornment ‘Bouglou’ as well as the risk factors for penile cancer in this region of Amazonia.
Gustavo Barbosa Fernandes de Souza, Luis Pena, Thiago Teixeira, Maira Tongu, Jorge Hallak, Raiza Marques Vieira Campos   +5 more
openaire   +2 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

An update on treatment of penile cancer

Therapeutic Advances in Medical Oncology, 2022
Penile cancer is a rare malignancy, particularly in industrialized nations. In the United States, rates are approximately less than 1 per 100,000 men per year with just over 2000 new cases per year. However, there is significantly increased prevalence in developing nations, with limited treatment expertise and reduced access to care, further driving ...
Juskaran Chadha, Jad Chahoud, Philippe E. Spiess   +2 more
openaire   +3 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

SPP1 is associated with adverse prognosis and predicts immunotherapy efficacy in penile cancer

Human Genomics, 2023
Background The effect of SPP1 in squamous cell carcinoma of the penis (PSCC) remained unknown. We attempted to clarify the function of the SPP1 gene in PSCC.
Yuantao Zou, Xingliang Tan, Gangjun Yuan, Yi Tang, Yanjun Wang, Cong Yang, Sihao Luo, Zhiming Wu, Kai Yao   +8 more
doaj   +1 more source

Evaluation of the Guidelines for Penile Cancer Treatment: Overview and Assessment

Société Internationale d’Urologie Journal, 2021
IntroductionMedical organizations have provided evidence-based guidelines for penile cancer treatment. This current review aims to compare and appraise guidelines on penile cancer treatment to provide a useful summary for clinicians.
Abdulmajeed Aydh, Shahrokh F. Shariat, Reza Sari Motlagh, Ekaterina Laukhtina, Fahad Quhal, Keiichiro Mori, Hadi Mostafaei, Andrea Necchi, Benjamin Pradere
doaj   +1 more source

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

FEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei, Amir Barzegar Behrooz, Marco Cordani, Mahmoud Aghaei, Negar Azarpira, Daniel J. Klionsky, Saeid Ghavami   +6 more
wiley   +1 more source

Evaluating and forecasting the associated main flavor components in Baijiu (Chinese distilled spirits) with alcohol metabolism and hangover symptoms through mice acute withdrawal model

Food Science &Nutrition, Volume 11, Issue 1, Page 334-343, January 2023., 2023
Chinese distilled spirits (Baijiu) is one of the most favourite alcohol beverages. The flavor quality of Baijiu is supposed to be one of the key factors which caused the hangover. However, little systematic study has been done to estimate the flavors effects on the hangover in the different aroma‐type of Baijiu.
Jie Huangfu, Jun Lu, Changwen Li, Deliang Wang, Chunguang Luan, Xin Jiang, Tao Song, Wei Jiang, Xinlin Han, Jing Feng, Yanli Liu, Mengchao He   +11 more
wiley   +1 more source