Results 41 to 50 of about 24,184 (337)

The Proportion of p16 Expression in Penile Squamous Cell Carcinoma Based on Immunohistochemistry Examination in the Balinese Population

Indonesian Journal of Cancer, 2022
Background: : Penile cancer is a rare type of cancer in men and was the highest in Bali compared to other regions in Indonesia. Around 95% of malignancies in the penis are squamous cell carcinoma (SCC) type. One of the risk factors associated with penile
Komang Ariningrum Dwita Lestari Ardhaputri , Desak Putu Oki Lestari , Ni Wayan Armerinayanti, Ni Luh Putu Eka Kartika Sari, Luh Yeni Laksmini , I Made Jati Luhur , I Nyoman Upadana, Kadek Pramesti Dewi   +7 more
doaj   +1 more source

The Association of Circumcision and Genitourinary Cancer, Especially Penile Cancer and Prostate Cancer: A 30-Year Systematic Review and Meta-Analysis

Indonesian Journal of Cancer
Background: The relationship between genitourinary cancer and circumcision has been debated for a long time. Two types of genitourinary cancer that are often discussed in relation to circumcision are penile cancer and prostate cancer.
Prima Ardiansah Surya, Alfin Putratama, Radika Naufal Hadi Surya, I Gede Yogi Prema Ananda   +3 more
doaj   +1 more source

Penile cancer trends and economic burden in the Brazilian public health system

Einstein (São Paulo), 2020
Objective: To gather information on penile cancer epidemiologic trends and its economic impact on the Brazilian Public Health System across the last 25 years.
Fernando Korkes, Antônio Flávio Silva Rodrigues, Willy Baccaglini, Frederico Timóteo Silva Cunha, Júlio Slongo, Philippe Spiess, Sidney Glina   +6 more
doaj   +2 more sources

PD-1 inhibitor treatment in a penile cancer patient with MMR/MSI status heterogeneity: A case report

Human Vaccines & Immunotherapeutics, 2022
Penile cancer is a rare malignant disease. Paclitaxel combined with platinum is often used as a first-line chemotherapeutic regimen for late-stage penile cancer, and there is no standard second-line treatment.
YunYi Du, XiaoLing Zhang, Ying Zhang, WeiLing Li, WenQing Hu, Liang Zong, Jun Zhao   +6 more
doaj   +1 more source

Is body mass index a risk factor for lymphnode metastasis in penile cancer? [PDF]

BMC Cancer
Roberto Días Machado, Eliney Ferreira Faria, Antônio Rodrigues Ferreira Júnior, Filipe Stirpari, Rafael Neuppmann Feres, Philippe E. Spiess, Shahrokh F. Shariat, Leonardo Oliveira Reis, Rodolfo Borges dos Reis   +8 more
openalex   +2 more sources

Experimental Models for Studying HPV-Positive and HPV-Negative Penile Cancer: New Tools for An Old Disease

, 2021
Penile cancer is an uncommon malignancy that occurs most frequently in developing countries. Two pathways for penile carcinogenesis are currently recognized: one driven by human papillomavirus (HPV) infection and another HPV-independent route, associated
Rui M. Gil da Costa, Haissa Brito, Antonio Cubilla, Tânia Martins, Beatriz Medeiros-Fonseca, Rui Medeiros, Paula Oliveira   +6 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source