Results 61 to 70 of about 18,088 (262)

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang   +11 more
wiley   +1 more source

Plexiform Schwannoma of the Penis: A Rare Subtype of Genital Schwannoma

open access: yesCase Reports in Urology, 2019
Schwannomas are benign, encapsulated neurogenic tumors which present in diverse histological subtypes despite the limited variety of their cellular constituents.
Chrysovalantis Gkekas   +7 more
doaj   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

open access: yesAdvanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang   +8 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

open access: yesAdvanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib   +8 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

open access: yesAdvanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai   +9 more
wiley   +1 more source

Penile carcinoma: what dermatologists need to know

open access: yesRevista da Sociedade Portuguesa de Dermatologia e Venereologia, 2023
Penile cancer is a rare disease in developed countries and is frequently underrecognized by clinicians leading to delays in diagnosis and treatment. Squamous cell carcinoma (SCC) is the predominant pathological entity, representing 95% of all penile ...
Maria J. Guimarães   +3 more
doaj  

Bilateral fracture of corpora cavernosa with complete rupture of the anterior urethra: Case report and review of recent findings for surgical management

open access: yesRevista de la Facultad de Medicina, 2018
Introduction: Penile fracture is a rare urological emergency associated in up to 30% of cases with injury to the anterior urethra. Recent data suggest that early surgical intervention is the best treatment strategy.
David Andrés Castañeda-Millán   +3 more
doaj   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano   +10 more
wiley   +1 more source

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

open access: yesAdvanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao   +10 more
wiley   +1 more source

Clinical Results of Penile Prosthesis Implantation for Treating Organic Erectile Dysfunction

open access: yesİstanbul Medical Journal, 2016
Introduction: This study aimed to evaluate the clinical results of penile prosthesis implantation for treating patients with organic erectile dysfunction (ED).Methods: Between January 2006 and December 2015, medical records of penile prosthesis ...
Mustafa Kadıhasanoğlu   +4 more
doaj   +1 more source

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