Results 141 to 150 of about 165,661 (337)

Evaluation of the acute toxicity and 28‐days subacute toxicity of the alcoholic extract from Ganoderma leucocontextum

open access: yesFood Science &Nutrition, Volume 11, Issue 1, Page 434-442, January 2023., 2023
The toxicity of Ganoderma leucocontextum was evaluated for the first time. No toxicological changes were found in acute and subacute toxicity test. Ganoderma leucocontextum showed a good safety profile in animal study. Abstract Ganoderma leucocontextum is a well‐known traditional medicine in Tibet Autonomous Region, which has benefits, such as anti ...
Shizhan Deng   +4 more
wiley   +1 more source

The Effects of Propofol, Sodium Pentobarbital, and Ketamine Hydrochloride on \u3ci\u3eIn Vitro\u3c/i\u3e Mouse Embryonic Development [PDF]

open access: yes, 2015
Every year more than 75,000 pregnant women are exposed to teratogenic medications or general anesthesia during non-obstetric surgery in the US,1-4 and embryonic effects of general anesthesia are of particular interest in laboratory research and ...
Balak, Tyler C.
core   +1 more source

Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration

open access: yesAdvanced Science, EarlyView.
A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou   +9 more
wiley   +1 more source

Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia

open access: yesGlia, Volume 71, Issue 2, Page 334-349, February 2023., 2023
Main Points Defined a pig microglial transcriptome signature comprising 239 genes. Demonstrated regional variance in the pig microglial transcriptome across the brain. Revealed similarity of pig microglial gene expression to that of human and mouse microglia.
Barbara B. Shih   +8 more
wiley   +1 more source

Investigations of the effects on the blood glucose levels of surgery and general anaesthesia with xylazine -ketamine and xylazine-pentobarbital sodium in healthy dogs [PDF]

open access: yesEurasian Journal of Veterinary Sciences
In this study, the effects of surgery and general anaesthesia that is with xylazine -ketamine hydrochloride and xylazine-pentobarbital sodium used commonly in carnivore, on the blood glucose levels, were investigated.
Celal İzci   +3 more
doaj  

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao   +7 more
wiley   +1 more source

Alterations in microglial morphology concentrate in the habitual sleeping period of the mouse

open access: yesGlia, Volume 71, Issue 2, Page 366-376, February 2023., 2023
Main Points We found regional differences of microglial morphology between the somatosensory cortex (SC), hippocampus (HC) and basal forebrain (BF). Cortical‐, but not HC‐ or BF microglial cell sizes negatively correlate with non‐REM sleep slow wave activity.
Sarah Katharina Steffens   +2 more
wiley   +1 more source

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

open access: yesAdvanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang   +13 more
wiley   +1 more source

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