Results 141 to 150 of about 173,582 (269)

Compression suture: A method for simulating intervertebral disc degeneration in rats induced by excessive loading

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In the compression suture group, a 5‐mm‐wide tail skin was removed, and then the defect was sutured to apply compressive force to the intervertebral disc. In the sham group, only the 5‐mm‐wide tail skin was removed without a compression suture. Compression suturing triggers apoptosis, inflammatory response, and imbalance of extracellular matrix ...
Xuening Liu   +4 more
wiley   +1 more source

Infusions of rocuronium and cisatracurium exert different effects on rat diaphragm function [PDF]

open access: yes, 2007
DECRAMER, M   +5 more
core  

Establishment and multifaceted characterization of a graded spinal cord injury model based on graduated impact depth

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We established a graded spinal cord injury (SCI) model based on graduated impact depth, which was subsequently characterized across multiple dimensions, including locomotor function, imaging, histology, and transcriptomic profiles. We further identified transcriptomic changes in graded SCI at different time points postinjury and investigated the ...
Gang Zhou   +6 more
wiley   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong   +5 more
wiley   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao   +5 more
wiley   +1 more source

A New Experimental Model of ARDS and Pulmonary Hypertension in the Dog [PDF]

open access: yes, 1989
Forst, Helmuth   +3 more
core   +1 more source

Hominoid‐specific calretinin‐immunopositivity of the optic radiation (geniculocalcarine tract)

open access: yesThe Anatomical Record, EarlyView.
Calretinin‐immunostained coronal section through the primary (V1) and extrastriate (ExSt) cortex of the lar gibbon. Note that the optic radiation (OR) is strongly calretinin‐immunoreactive. This calretinin‐immunopositivity of the OR distinguishes the Hominoidea from other primates in terms of the neurochemistry of the OR.
Nelyane N. M. Santana   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy