Results 151 to 160 of about 139,649 (278)

Phenytoin Derivatives as Antagonists of AMPA Receptors and Voltage-Gated Sodium Channels: A Structure-Function Study. [PDF]

Int J Mol Sci
Zhigulin AS, Nikolaev MV, Dron MY, Vasilenko DA, Barygin OI, Tikhonov DB.   +5 more
europepmc   +1 more source

Pentobarbital Enhances GABAergic Neurotransmission to Cardiac Parasympathetic Neurons, Which Is Prevented by Expression of GABAAε Subunit

, 2002
BACKGROUND: Pentobarbital decreases the gain of the baroreceptor reflex on the order of 50%, and this blunting is caused nearly entirely by decreasing cardioinhibitory parasympathetic activity. The most likely site of action of pentobarbital is the gamma-
Mendelowitz, David, Wang, Jijiang, Irnaten, Mustapha, Andresen, Michael C., Hales, Tim G; id_orcid, Walwyn, Wendy M., Chang, Kyoung S. K., Evans, Cory, Venkatesan, Priya   +8 more
core  

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Precision ventral extraction of implanted mouse brains: A protocol. [PDF]

STAR Protoc
El-Fayomi L, Bergamini M, van der Kooy D.   +2 more
europepmc   +1 more source

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source

<i>Prunella vulgaris</i> Compound Improves Sleep Architecture and Attenuates Hippocampal Injury in Insomnia Mice. [PDF]

Life (Basel)
Wang K, Zhang H, Zhou C, Sun Z, Shao W, Liu K, Ma W, Wang C, Wang X, Wang Q, Jiang Y, Cheng F.   +11 more
europepmc   +1 more source

Effects of intermittent exposure to hypobaria and cold on the microarchitecture and morphofunctional profile of rat gastrocnemius muscle

The Anatomical Record, EarlyView.
Abstract Intermittent hypobaric hypoxia (IHH) enhances oxygen transport, muscle metabolism, and cardiovascular health; however, the combined effects of hypobaria and cold are less well understood. Exposure to these stressful environmental factors, even intermittently, can affect skeletal muscle due to its plasticity, thereby altering its metabolic and ...
Garoa Santocildes, Teresa Pagès, Ginés Viscor, Joan Ramon Torrella   +3 more
wiley   +1 more source

Anterior Cingulate Cortex Projections to the Amygdala in Primates: Topographic and Layer-Specific Organization Underlying Emotion and Mood Regulation. [PDF]

J Neurosci
Kimura K, Soga Y, Yoshino R, Zheng A, Nonomura S, Yan G, Tanabe S, Nakamura S, Ohara S, Inoue KI, Takada M, Tsutsui KI.   +11 more
europepmc   +1 more source

Effects of oropharyngeal neuromuscular stimulation on the volumetric enlarged and reduced tongue base in minipigs

The Anatomical Record, EarlyView.
Abstract Hypoglossal nerve or tongue protruding muscle stimulation is a current treatment option for obstructive sleep apnea. Thus, the present study analyzed 3D deformations of the volumetric enlarged and reduced tongue base upon oropharyngeal neuromuscular stimulation.
Sydney Chen, Doris Haydee Rosero Salazar, Zi‐Jun Liu   +2 more
wiley   +1 more source

Electroacupuncture Attenuates Neuroinflammation in PCPA-Induced Insomnia Rats by Suppressing the TLR4/MyD88/NF-κB p65 Pathway and M1 Microglial Activation. [PDF]

Neuropsychiatr Dis Treat
Zhang M, Liu L, Tan T, He L, Hu B, Li S, Jiang M, Deng P, Ren Q.   +8 more
europepmc   +1 more source