Epilepsia, EarlyView.Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil +4 more
wiley +1 more source
Preventive and therapeutic effects of ginsenosides on myocardial ischemia-reperfusion injury in animal models: a systematic review and meta-analysis. [PDF]
BMC Cardiovasc DisordYue H, Jia Y, Sun R, Song Z, Li W.
europepmc +1 more source
Paroxysmal slow waves mark ictal networks
Epilepsia, EarlyView.Abstract Objective Epilepsy diagnosis and treatment monitoring are hindered by the episodic, heterogeneous expression of seizures and by normal‐appearing scalp electroencephalography (EEG) in many patients. We previously described paroxysmal slow‐wave events (PSWEs), brief epochs of broadband slowing detectable on EEG in people with epilepsy.
Florent J. M. Boyer‐Aymé +13 more
wiley +1 more source
Euthanasia Methods in Invertebrates: A Critical Narrative Review of Methodological and Welfare Standards. [PDF]
Animals (Basel)Bakker J +8 more
europepmc +1 more source
Anterior cingulate cortex neuron subtypes differentially regulate seizures
Epilepsia, EarlyView.Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan +12 more
wiley +1 more source
Epilepsy surgery: From bench to the clinics
Epilepsia Open, EarlyView.Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley +1 more source
Chrysanthemum morifolium extract protects HT22 cells from oxidative stress and enhances sleep via GABAergic modulation: contribution of luteolin-7-glucoside. [PDF]
J Sci Food AgricKim H +6 more
europepmc +1 more source
Neonatal seizures and GABAergic drugs: Scylla and Charybdis?
Epilepsia Open, EarlyView.Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson +2 more
wiley +1 more source
Properties of Acute Activation and Inhibition of the β3 Homomeric GABA<sub>A</sub> Receptor Mediated by Protonation of Conserved Histidine Residues. [PDF]
ACS Chem NeurosciPierce SR +8 more
europepmc +1 more source
Equine Veterinary Journal, EarlyView.Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee +4 more
wiley +1 more source