Results 181 to 190 of about 173,723 (335)
This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.
Birong Peng+8 more
wiley +1 more source
Zhi-zi-chi decoction exerts hypnotic effect through gut-brain axis modulation in insomnia mice. [PDF]
Wang Q+9 more
europepmc +1 more source
A New Experimental Model of ARDS and Pulmonary Hypertension in the Dog [PDF]
Forst, Helmuth+3 more
core +1 more source
Studies of the Possible Role of Brain Endorphins in Pentobarbital Anesthesia and Toxicity in Mice [PDF]
H N Bhargava
openalex +1 more source
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng+7 more
wiley +1 more source
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao+14 more
wiley +1 more source
Current Management and Future Challenges in the Management of Severe Traumatic Brain Injury. [PDF]
Russo L, Kazmi A, Ahmed N.
europepmc +1 more source