A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors. [PDF]
PLoS ONE, 2016 BACKGROUND:Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that pentobarbital binds to some of the same sites where propofol and etomidate act.
Alexis M Ziemba, Stuart A Forman
doaj +1 more source
Defining a “Good Death”: Exploring Veterinarians’ Perceptions of Companion Animal Euthanasia
Animals, 2023 This study was designed to determine how veterinarians define a good euthanasia experience. This information is used to generate a working definition of companion animal euthanasia that aligns with animal welfare standards and pet owners’ expectations ...
Lori R. Kogan, Kathleen A. Cooney
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Comparison of the effects of propofol and pentobarbital on hydrogen peroxide-stimulated hepatic SNU761 cells [PDF]
Korean Journal of Anesthesiology, 2010 BackgroundPropofol and barbiturates are both known to protect cells of several organs against ischemia/reperfusion injury, but there are few reports on any possible protective effects on human hepatocytes. We investigated the activities of both agents on
Ji Yeon Lee +5 more
doaj +1 more source
Pharmaceutics, 2023 Pentobarbital is a drug of choice to limit motion in children during paediatric procedural sedations (PPSs). However, despite the rectal route being preferred for infants and children, no pentobarbital suppositories are marketed, and therefore they must ...
Matthieu Lebrat +10 more
doaj +1 more source
Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors [PDF]
Avicenna Journal of Phytomedicine, 2019 Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of Tanacetum parthenium was studied in mice. Material and Methods: The hydro-alcoholic extract (HAE) of T.
Fatemeh Forouzanfar +7 more
doaj +1 more source
Case report: Fatal poisoning caused by additive effects of two barbiturates
Frontiers in Pharmacology, 2023 A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 ...
Sella Takei +9 more
doaj +1 more source
Pentobarbital Anesthesia Suppresses the Glucose Response to Acute Intermittent Hypoxia in Rat
Frontiers in Physiology, 2021 A key feature of sleep disordered breathing syndromes, such as obstructive sleep apnea is intermittent hypoxia. Intermittent hypoxia is well accepted to drive the sympathoexcitation that is frequently associated with hypertension and diabetes, with ...
Polina E. Nedoboy +5 more
doaj +1 more source
Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
Translational Neuroscience, 2021 During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies) during the wake–sleep cycle.
Lahogue Caroline, Pinault Didier
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Lessons and Recommendations from a Pentobarbital Shortage: US and Canada 2021
Animals, 2022 In 2021, a shortage in the supply of the euthanasia drug pentobarbital sodium affected animal care professionals around the world, including in the United States and Canada.
Kathleen Cooney, Lianna Titcombe
doaj +1 more source