Results 11 to 20 of about 52,516 (291)

Unexpected epileptogenic effect of lethal doses of pentobarbital: a case report [PDF]

open access: yesJournal of Neurocritical Care, 2023
Background Barbiturate poisoning is rare but potentially fatal. Case Report We reported a case of barbiturate poisoning in a 28-year-old woman who recovered from lethal pentobarbital deliberate self-poisoning.
Amélie Giudicelli-Bailly   +5 more
doaj   +1 more source

Thermal Response of Laboratory Rats (Rattus norvegicus) during the Application of Six Methods of Euthanasia Assessed by Infrared Thermography

open access: yesAnimals, 2023
Refinement is one of the principles aiming to promote welfare in research animals. The techniques used during an experimental protocol, including euthanasia selection, must prevent and minimize suffering.
Adriana Domínguez-Oliva   +5 more
doaj   +1 more source

A Comparison of Epileptogenic Effect of Status Epilepticus Treated With Diazepam, Midazolam, and Pentobarbital in the Mouse Pilocarpine Model of Epilepsy

open access: yesFrontiers in Neurology, 2022
Status epilepticus (SE) is a medical emergency associated with acute severe systemic damage and high mortality. Moreover, symptomatic SE is one of the highest risk factors for epileptogenesis.
Xiangzhen Tong   +9 more
doaj   +1 more source

Defining a “Good Death”: Exploring Veterinarians’ Perceptions of Companion Animal Euthanasia

open access: yesAnimals, 2023
This study was designed to determine how veterinarians define a good euthanasia experience. This information is used to generate a working definition of companion animal euthanasia that aligns with animal welfare standards and pet owners’ expectations ...
Lori R. Kogan, Kathleen A. Cooney
doaj   +1 more source

Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors [PDF]

open access: yesAvicenna Journal of Phytomedicine, 2019
Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of Tanacetum parthenium was studied in mice.  Material and Methods: The hydro-alcoholic extract (HAE) of T.
Fatemeh Forouzanfar   +7 more
doaj   +1 more source

Development and Stability of a New Formulation of Pentobarbital Suppositories for Paediatric Procedural Sedation

open access: yesPharmaceutics, 2023
Pentobarbital is a drug of choice to limit motion in children during paediatric procedural sedations (PPSs). However, despite the rectal route being preferred for infants and children, no pentobarbital suppositories are marketed, and therefore they must ...
Matthieu Lebrat   +10 more
doaj   +1 more source

Comparison of the effects of propofol and pentobarbital on hydrogen peroxide-stimulated hepatic SNU761 cells [PDF]

open access: yesKorean Journal of Anesthesiology, 2010
BackgroundPropofol and barbiturates are both known to protect cells of several organs against ischemia/reperfusion injury, but there are few reports on any possible protective effects on human hepatocytes. We investigated the activities of both agents on
Ji Yeon Lee   +5 more
doaj   +1 more source

Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors. [PDF]

open access: yesPLoS ONE, 2016
BACKGROUND:Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that pentobarbital binds to some of the same sites where propofol and etomidate act.
Alexis M Ziemba, Stuart A Forman
doaj   +1 more source

Case report: Fatal poisoning caused by additive effects of two barbiturates

open access: yesFrontiers in Pharmacology, 2023
A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 ...
Sella Takei   +9 more
doaj   +1 more source

Pentobarbital Anesthesia Suppresses the Glucose Response to Acute Intermittent Hypoxia in Rat

open access: yesFrontiers in Physiology, 2021
A key feature of sleep disordered breathing syndromes, such as obstructive sleep apnea is intermittent hypoxia. Intermittent hypoxia is well accepted to drive the sympathoexcitation that is frequently associated with hypertension and diabetes, with ...
Polina E. Nedoboy   +5 more
doaj   +1 more source

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