Results 211 to 220 of about 173,723 (335)

PDZK1 Protects Against RPE Senescence by Targeting the 14‐3‐3ε‐mTOR Axis to Attenuate Early Diabetic Retinopathy

Advanced Science, EarlyView.
PDZK1 down‐regulation couples high‐glucose stress to RPE senescence via a PDZK1–14‐3‐3ε–mTOR axis. Restoring PDZK1 or clearing senescent cells rescues retinal homeostasis and mitigates early diabetic retinopathy (DR). This study provides direct evidence linking RPE cell senescence to DR pathogenesis and reveals a promising therapeutic strategy for DR ...
Jian Zhao, Junbiao Zhang, Yanli Liu, Lili Wang, Chunxi Huang, Wei Chi, Meixia An   +6 more
wiley   +1 more source

Sedation Methods in Paediatric Auditory Electrophysiologic Testing: A Narrative Review. [PDF]

Audiol Res
Necula V, Domuta ME, Olariu R, Georgescu MG, Marchis IF, Stamate MC, Blebea CM, Dindelegan MG, Maniu AA, Pop SS.   +9 more
europepmc   +1 more source

Anesthesia and Digitalis VII. The Effect of Pentobarbital, Halothane, and Methoxyflurane on the A-V Conduction And Inotropic Responses to Ouabain

, 1972
Dean H. Morrow, John V. Haley, Joseph R. Logic   +2 more
openalex   +1 more source

An Injectable Zwitterionic Hydrogels with Multiple Intermolecular Interactions for Effective Prevention of Abdominal Adhesions

Advanced Science, EarlyView.
An injectable PSA‐ZnO through multiple intermolecular including hydrogen bonds and electrostatic interactions for effectively prevents abdominal adhesions. The PSA‐ZnO hydrogel demonstrates superior wound healing promotion (≥ 95%) and more effective inhibition of scar formation compared to the commercial 3M dressing (≈80%), and prevents post‐operative ...
Na Wen, Yating Jiang, Yunhao Song, Jiachao Yang, Jinlin Long, Ying Wang, Xunbin Yu, Shiyun Lu, Tianhua Zhou, Xueping Huang   +9 more
wiley   +1 more source

Canine Cerebral Metabolic Tolerance during 24 Hours Deep Pentobarbital Anesthesia [PDF]

, 1981
Gerald A. Gronert, John D. Michenfelder, Frank W. Sharbrough, James H. Milde   +3 more
openalex   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source

The Effect of Water-Soluble Alpinia Galanga Extract on Sleep and the Activation of the GABAAergic/Serotonergic Pathway in Mice. [PDF]

Pharmaceuticals (Basel)
Sahin K, Korkusuz AK, Sahin E, Orhan C, Er B, Morde A, Padigaru M, Kilic E.   +7 more
europepmc   +1 more source

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

Advanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao, Kaixi Shi, Wen Li, Jialin Liu, Pengfei Xie, Zijun Hu, Yu Dai, Haiyan Weng, Qiuju Yuan, Wutian Wu, Limin Rong, Liumin He   +11 more
wiley   +1 more source

Intravenous anesthetics have differential effects on human potassium channels. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Tao Y, Yao K, Wu J, Xu T, Lin J, Qin Y, Su D, Cai S, Yu W, Chen X.   +9 more
europepmc   +1 more source

Effect of Sodium Pentobarbital on the SA Nodal Activity of the Dog Heart <i>in vivo</i>

, 1972
Shigetoshi Chiba, Tamio Nakajima
openalex   +2 more sources