Results 191 to 200 of about 104,655 (257)

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Melatonin suppresses abnormal hyperexcitability of hippocampal CA1 neurons in early-stage oxygen-glucose deprivation. [PDF]

Front Pharmacol
Cui Y, Wang Q, Liu C, Zhou H.
europepmc   +1 more source

The role and regulatory mechanism of USP25 in pancreatic microcirculatory disturbance in severe acute pancreatitis. [PDF]

Sci Rep
Zhang Q, Zhang X, Shan F.
europepmc   +1 more source

Cepharanthine alleviates lipopolysaccharide-induced acute lung injury through modulating macrophage polarization. [PDF]

Sci Rep
Dang L, He B, Yang J, Liu J, Ding Y, Xin W.   +5 more
europepmc   +1 more source

Synergistic Therapeutic Effects of Tetrahydroberberine Combined with Protopanaxadiol on PCPA-Induced Insomnia in Rats: Involvement of the Microbiota-Gut-Brain Axis and Regulation of PI3K/AKT/AGE-RAGE Pathways. [PDF]

Pharmaceuticals (Basel)
Li M, Wang Y, Liang Z, Li H, Zhao Y, Kong L, Guo N, Dai G, Zhang G, Lu X, Yao J.   +10 more
europepmc   +1 more source

Novel insights into the protective role of crocetin from gardenia jasminoides against mitochondrial hypoxia. [PDF]

Sci Rep
Boshen L, Mingxia Z, Renjie W, Kai L, Qingyuan Q, Xiaolin L, Maoxing L.   +6 more
europepmc   +1 more source