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Injectable sodium pentobarbital: Stability at room temperature.
Journal of Pharmacological and Toxicological Methods, 2015Sodium pentobarbital (Nembutal) is a barbiturate used in research as an anesthetic in many animal models. The injectable form of this drug has lately become difficult to procure and prohibitively expensive. Due to this lack of availability, researchers have begun to compound injectable sodium pentobarbital from so-called "nonpharmaceutical ...
Sydney M. Priest, T. Geisbuhler
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Pentobarbital Sodium: Variation in Toxicity
Science, 1966The survival rate of groups of female mice given a standard dose of pentobarbital sodium varied during a 12-hour period. When survival rate was plotted against time, a curve with several inflections was described.
H. A. Lindsay, V. S. Kullman
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Pentobarbital Sodium Coma for Refractory Intracranial Hypertension
Journal of Neuroscience Nursing, 2003Refractory intracranial hypertension (RICH) is defined as intracranial pressures that exceed 25 mm Hg for 30 minutes, 30 mm Hg for 15 minutes, or 40 mm Hg for 1 minute. RICH occurs in approximately 15% of patients with traumatic brain injury. If it is not aggressively treated, RICH can result in cerebral herniation and death.
Joan L Censullo, S. Sebastian
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Pentobarbital suppresses human brain sodium channels
Molecular Brain Research, 1989Ion channels, key components in neuronal signal transmission and processing, are likely to be important molecular sites of anesthetic action. Sodium channels from human brain tissue were incorporated into planar lipid bilayers in the presence of batrachotoxin and exposed to the anesthetic pentobarbital.
C, Frenkel +3 more
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Animal Welfare, 2018
Small laboratory animals are commonly euthanased via intraperitoneal (IP) injection of sodium pentobarbital. However, there is concern that animals may experience pain prior to loss of consciousness with this delivery route.
N. Kells +3 more
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Small laboratory animals are commonly euthanased via intraperitoneal (IP) injection of sodium pentobarbital. However, there is concern that animals may experience pain prior to loss of consciousness with this delivery route.
N. Kells +3 more
semanticscholar +1 more source
Pentobarbital Sodium Anesthesia in the Syrian Hamster*
Journal of the American Pharmaceutical Association (Scientific ed.), 1946The Syrian hamster (Cricetus auratus) was studied to determine an effective dosage of pentobarbital sodium in relation to the length and depth of general anesthesia produced. In general, the hamster has an apparently greater tolerance to pentobarbital sodium both in anesthetic and lethal doses than the rat, guinea pig, or rabbit.
F J, ORLAND, P M, ORLAND
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Inhibition of monoamine oxidase by sodium pentobarbital
Canadian Journal of Biochemistry, 1970A single intraperitoneal injection of 30, 60, or 90 mg/kg of sodium pentobarbital into male rats produced an appreciable inhibition of monoamine oxidase activity of liver and heart. The brain and kidney activities were practically unaffected. Chronic administration of pentobarbital, 30 mg/kg daily for 20 days, did, however, produce an inhibition of ...
E, Quevedo, A, D'Iorio
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