Drugs for preventing red blood cell dehydration in people with sickle cell disease. [PDF]
, 2016 BACKGROUND: Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells. These are rigid and may block blood vessels leading to acute painful crises and other complications.
Ballas, Samir K., Nagalla, Srikanth
core +2 more sources
Prednisolone or pentoxifylline for alcoholic hepatitis [PDF]
, 2015 BACKGROUND: Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use.
Allison, Michael +23 more
core +1 more source
Oxidative stress: new insights on the association of nonalcoholic fatty liver disease and atherosclerosis [PDF]
, 2015 Non-alcoholic fatty liver disease (NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH), which may progress ...
Albanese, Fabiana +7 more
core +1 more source
APRI Index Changes After 4 Weeks Treatment of Pentoxifylline in Chronic Hepatitis B [PDF]
, 2008 Nowadays studies have shown that liver fibrosis is a reversible process. Theraupetic target on hepatic stellate cell (HSC) through inhibition of fibrotic signaling transduction is one of the way to treat liver fibrosis (e.g. pentoxifylline).
Zain, L. H. (Lukman) +1 more
core +2 more sources
Bicarbonate is required for migration of sperm epididymal protein DE/CRISP-1 to the equatorial segment and expression of rat sperm fusion ability [PDF]
, 2004 Numerous studies have demonstrated that sperm capacitation is a bicarbonate-dependent process. In the rat, capacitation has not been studied as much as in other species, mainly because of the difficulties in carrying out functional assays with this ...
Busso, Dolores +6 more
core +1 more source
EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis [PDF]
, 2004 BACKGROUND: Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro.
Beier, Norbert +2 more
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Photodynamic Therapy of Necrobiosis Lipoidica - A Multicenter Study of 18 Patients [PDF]
, 2008 Background: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease.
Arenberger, P. +4 more
core +1 more source
Clinical features of alcoholic hepatitis in latinos and caucasians: A single center experience. [PDF]
, 2017 AimTo study differences of presentation, management, and prognosis of alcoholic hepatitis in Latinos compared to Caucasians.MethodsWe retrospectively screened 876 charts of Caucasian and Latino patients who were evaluated at University of California ...
Durbin-Johnson, Blythe +3 more
core +1 more source
Photoelectrochemical Iron(III) Catalysis for Late‐Stage C─H Fluoroalkylations
Angewandte Chemie International Edition, EarlyView.Efficient electrophotochemical C─H fluoroalkylation of complex bioactive substrates with abundant fluoroalkyl carboxylic acids employing an inexpensive iron(III) catalyst accompanied by hydrogen evolution reaction has been developed. Abstract Chemo‐ and site‐selective functionalization of complex molecules poses a fundamental challenge.
Vladimir Motornov +8 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source