Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease
BJU International, Volume 135, Issue 5, Page 810-817, May 2025.Objectives To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.
Sophie L. Harding +4 more
wiley +1 more source
Disruption of Hepatic Sinusoidal Homeostasis Leads to Hepatopulmonary Syndrome
Journal of Cellular and Molecular Medicine, Volume 29, Issue 9, May 2025.ABSTRACT Hepatopulmonary syndrome (HPS) is a pulmonary vascular complication of liver disease and/or portal hypertension. HPS manifests as impaired gas exchange and hypoxemia due to intrapulmonary vascular dilatations and shunts. In response to primary liver disease, the abnormal adaptation of respiratory epithelial cells, pulmonary endothelial cells ...
Jiaxin Chen +7 more
wiley +1 more source
Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models
Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.This review discusses kidney diseases with a focus on kidney fibrosis and the models currently used. It highlights the limitations of animal and 2D in vitro models in replicating human kidney anatomy and physiology. Consequently, there is a significant need for humanized 3D in vitro models, such as 3D cell aggregates, membranes and hydrogels, on‐chip ...
Gabriele Addario +2 more
wiley +1 more source
Treatment of Schamberg's disease with pentoxifylline - therapeutic trial [PDF]
: Thirty patients with Schamberg's disease were started on pentoxifylline (400 mg three times daily) for a period of 9 weeks. Improvement was assessed at 3 weekly intervals by two observers independently and graded as mild (50%). Marked improvement was
رستمی مقدم, مجید
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Collection and freezing of equine epididymal spermatozoa [PDF]
, 2014 The epididymis and vas deferens store an important number of fertile spermatozoa called the extragonadal sperm reserves. These stored spermatozoa can be collected in an ultimate attempt to preserve viable spermatozoa of a critically ill or dying stallion.
Govaere, Jan +5 more
core +1 more source
Pre-term pre-labour rupture of membranes and the role of amniocentesis [PDF]
, 2010 Pre-labour premature rupture of membranes (PPROM) is defined as rupture of membranes more than 1 hour prior to the onset of labour at
Abi-Nader, KN, Kenyon, AP, Pandya, PP
core +1 more source
Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats [PDF]
, 2014 PURPOSE:To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline.METHODS:It was allocated into four groups (n=6), 24 male Wistar rats (200 to 250g) and ...
Aban N +41 more
core +2 more sources
Recent advances in interstitial lung disease research [PDF]
, 2006 The interstitial lung diseases are a diverse collection of disorders characterized by impaired gas exchange, restricted physiology on lung function testing, and diffuse parenchymal lung infiltrates on radiography.
Vassallo, Robert
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How does pentoxifylline affect survival of patients with alcoholic hepatitis? [PDF]
, 2008 Pentoxifylline improves short-term survival in patients admitted to the hospital with severe alcoholic hepatitis (strength of recommendation [SOR]: B, a single published randomized controlled trial [RCT]). Pentoxifylline does not improve survival when it
Ghavami, Parham +2 more
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Systemic treatment in severe cases of recurrent aphthous stomatitis: an open trial [PDF]
, 2009 PURPOSE: This study aimed to evaluate the efficacy of the systemic drugs thalidomide, dapsone, colchicine, and pentoxifylline in the treatment of severe manifestations of RAS.
HIROTA, Silvio Kenji +4 more
core +5 more sources