Results 91 to 100 of about 68,712 (302)

HIV and hepatitis C Virus in internally displaced people with and without injection drug use experience in the region of Shida Kartli, Georgia

BMC Research Notes
Objective Internally displaced persons (IDPs) can have limited access to HIV and hepatitis C Virus (HCV) treatment and prevention. IDPs comprise > 7% of Georgian population but prevalence and levels of HIV and HCV knowledge in this population remain ...
Adrian Trovato, Maka Gogia, Ana Aslanikashvili, Tamuna Kasrashvili, Ganna Kovalenko, Anna Yakovleva, Britt Skaathun, Tetyana I. Vasylyeva   +7 more
doaj   +1 more source

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

A missing perspective: injectable pre-exposure prophylaxis for people who inject drugs

AIDS Care, 2019
The efficacy of pre-exposure prophylaxis (PrEP) for HIV prevention has been established among people who inject drugs (PWID). HIV uninfected, at risk PWID, could likely benefit from long-acting injectable formulations of PrEP ("LAI-PrEP"); however, its acceptability in this population has not been previously documented. Thirty-three HIV-uninfected PWID
K. B. Biello, A. Edeza, P. Salhaney, D. L. Biancarelli, M. J. Mimiaga, M. L. Drainoni, E. S. Childs, A. R. Bazzi   +7 more
openaire   +3 more sources

Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs [PDF]

, 2017
In the developed world, the majority of new and existing hepatitis C virus (HCV) infections occur among people who inject drugs (PWID). The burden of HCV-related liver disease in this group is increasing, but treatment uptake among PWID remains low ...
Arain, Amber, Backmund, Markus, Bruggmann, Philip, Dalgard, Olav, De Gottardi, Andrea, Dore, Gregory J., Grebely, Jason, Kautz, Achim, Mauss, Stefan, Moussalli, Joseph, Prins, Maria, Robaeys, Geert, Schaefer, Martin, Stöver, Heino, Swan, Tracy, Taylor, Lynn, Wedemeyer, Heiner   +16 more
core  

Needle syringe programmes and opioid substitution therapy for preventing hepatitis C transmission in people who inject drugs. [PDF]

, 2017
BACKGROUND: Needle syringe programmes and opioid substitution therapy for preventing hepatitis C transmission in people who inject drugsNeedle syringe programmes (NSP) and opioid substitution therapy (OST) are the primary interventions to reduce ...
Allen, Amato, Ameijden, Aspinall, Aubisson, Azim, Bayoumi, Beek, Berg, Bluthenthal, Bourgois, Bruandet, Bruneau, Burt, Buxton, Chun, Collins, Cox, Craine, Crofts, Crofts, Degenhardt, Duan, Dubois-Arber, Emmanuelli, Emmanuelli, Esmaeili, Esteban, Faggiano, Falster, Fatseas, Fhima, Fudala, Fuller, Galeazzl, Gambashidze, Garfein, Garfein, Garten, Gervasoni, Gibson, Gibson, Goldberg, Goldberg, Goswami, Gower, Gowing, Grebely, Grebely, Guadagnino, Guyatt, Guyatt, Hagan, Hagan, Hagan, Hagan, He, He, Heimer, Higgins, Higgs, Hoek, Holtzman, Hope, Hope, Iversen, Jackson, Jarlais, Jarlais, Javanbakht, Jones, Judd, Kaplan, Kwon, Laar, Laar, Lai, Larney, Lucidarme, MacArthur, Mansson, Mathei, Mathers, Mathers, Mikolajczyk, Miller, Mohd Hanafiah, Moshkovich, Muga, Nasir, Nolan, O'Keefe, Page, Page, Page, Palmateer, Palmateer, Palmateer, Palmateer, Paquette, Parrino, Patrick, Pedrana, Peles, Perz, Platt, Platt, Platt, Pollack, Pouget, Pratt Udeagu, Ray Saraswati, Rezza, Robotin, Rohrig, Roux, Roux, Roy, Roy, Roy, Ruan, Ruan, Samo, Sanders-Buell, Santen, Schünemann, Seal, Selvey, Selvey, Sendi, Shannon, Shi, Siedentopf, Solomon, Spencer, Spittal, Steffen, Stein, Stephens, Stephens, Sterne, Strathdee, Strathdee, Sullivan, Sylvestre, Tait, Tait, The GRADE working group, Thiede, Thorpe, Tilson, Todd, Tracy, Tsirogianni, Tsui, Tsui, Turner, UNAIDS, Valdez, Vallejo, Vickerman, Vickerman, Villano, Vorma, Vos, Wada, Wand, Wang, White, Widell, Wiessing, Winkelstein, Wodak, Wood, Woody, World Health Organization, Yang, Yen, Zhang, Zhao, Zhou, Zou, Zunt   +182 more
core   +5 more sources

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Reported xylazine exposure highly associated with overdose outcomes in a rapid community assessment among people who inject drugs in Baltimore

Harm Reduction Journal
Background Addressing xylazine harms are now a critical harm reduction priority, but relatively little epidemiological information exists to determine prevalence, magnitude, and correlates of xylazine use or related outcomes. Methods We conducted a rapid
Danielle German, Becky Genberg, Olivia Sugarman, Brendon Saloner, Anne Sawyer, Jennifer L. Glick, Molly Gribbin, Colin Flynn   +7 more
doaj   +1 more source

HIV treatment cascade among people who inject drugs in Ukraine.

PLoS ONE, 2020
The HIV treatment cascade is an effective tool to track progress and gaps in the HIV response among key populations. People who inject drugs (PWID) remain the most affected key population in Ukraine with HIV prevalence of 22% in 2015.
Yana Sazonova, Roksolana Kulchynska, Yuliia Sereda, Marianna Azarskova, Yulia Novak, Tetiana Saliuk, Marina Kornilova, Mariia Liulchuk, Charles Vitek, Kostyantyn Dumchev   +9 more
doaj   +1 more source

Human Immunodeficiency Virus Infection in Young Adults: Treatment of Substance Use Disorders as a Priority Component of HIV Prevention, Care and Treatment in Low and Middle Income Countries [PDF]

, 2016
Young adults comprise roughly one-quarter of the global population and are at the developmental stage where personal life goals are formulated and personal independence is obtained.
Kresina TF, Kaplowitz L, Johnson K
core   +1 more source