Results 101 to 110 of about 102,707 (301)

Strategies to maximise study retention and limit attrition bias in a prospective cohort study of men reporting a history of injecting drug use released from prison: the prison and transition health study

BMC Medical Research Methodology, 2021
Background There are significant challenges associated with studies of people released from custodial settings, including loss to follow-up in the community. Interpretation of findings with consideration of differences between those followed up and those
Ashleigh Cara Stewart, Reece Cossar, Shelley Walker, Anna Lee Wilkinson, Brendan Quinn, Paul Dietze, Rebecca Winter, Amy Kirwan, Michael Curtis, James R. P. Ogloff, Stuart Kinner, Campbell Aitken, Tony Butler, Emma Woods, Mark Stoové   +14 more
doaj   +1 more source

HIV Prevention, Treatment, and Care for People Who Inject Drugs [PDF]

Journal of Infectious Diseases, 2013
(See the major article by Liu et al on pages 442–53.) Significant advances have been made in recent years in controlling the human immunodeficiency virus (HIV) epidemic. The number of people newly infected with HIV is declining globally [1], whereas antiretroviral therapy (ART) has dramatically decreased HIV-related mortality [2] and is now an ...
Sarah, Larney, Nickolas D, Zaller, Josiah D, Rich   +2 more
openaire   +2 more sources

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

The effect of public health-oriented drug law reform on HIV incidence in people who inject drugs in Tijuana, Mexico: an epidemic modelling study

The Lancet Public Health, 2018
Summary: Background: As countries embark on public health-oriented drug law reform, health impact evaluations are needed. In 2012, Mexico mandated the narcomenudeo reform, which depenalised the possession of small amounts of drugs and instituted drug ...
Annick Borquez, PhD, Leo Beletsky, JD, Bohdan Nosyk, PhD, Steffanie A Strathdee, ProfPhD, Alejandro Madrazo, ProfJSD, Daniela Abramovitz, MS, Claudia Rafful, PhD, Mario Morales, MA, Javier Cepeda, PhD, Dimitra Panagiotoglou, PhD, Emanuel Krebs, MA, Peter Vickerman, ProfDPhil, Marie Claude Boily, ProfPhD, Nicholas Thomson, PhD, Natasha K Martin, DPhil   +14 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Preferences and acceptability of law enforcement initiated referrals for people who inject drugs: a mixed methods analysis

Substance Abuse Treatment, Prevention, and Policy, 2020
Background Law enforcement officers (LEOs) come into frequent contact with people who inject drugs (PWID). Through service referrals, LEOs may facilitate PWID engagement in harm reduction, substance use treatment, and other health and supportive services.
Gabriella K. Olgin, Annick Bórquez, Pieter Baker, Erika Clairgue, Mario Morales, Arnulfo Bañuelos, Jaime Arredondo, Alicia Harvey-Vera, Steffanie Strathdee, Leo Beletsky, Javier A. Cepeda   +10 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Applying the Infectious Diseases Literature to People who Inject Drugs

Infectious Disease Clinics of North America, 2020
People who inject drugs (PWID) presenting with injection drug use-associated infections are an understudied population excluded from most prospective infectious disease (ID) clinical trials. Careful application of the existing ID literature to PWID must consider their unique medical, psychological, and social challenges. Identification and treatment of
David P, Serota, Teresa A, Chueng, Marcos C, Schechter   +2 more
openaire   +3 more sources

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

The use of alprazolam by people who inject drugs in Melbourne, Australia

Drug and Alcohol Review, 2011
AbstractIntroduction and Aims. In Australia, people who inject drugs (PWID) commonly report the use of benzodiazepines (BZDs). This paper explores the emerging use of alprazolam among PWID in Melbourne, Australia.Design and Methods. This study reports on 3 years of data collected through the Victorian Illicit Drug Reporting System (2008–2010 ...
Horyniak, Danielle, Reddel, Siobhan, Quinn, Brendan, Dietze, Paul   +3 more
openaire   +3 more sources