Results 81 to 90 of about 13,383,705 (258)

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Characteristics of people who inject drugs (PWID) enrolled in the study cohort (N = 252).

, 2019
Characteristics of people who inject drugs (PWID) enrolled in the study cohort (N = 252).
Carl Latkin (352048), Kenrad E. Nelson (110353), Hsiu-Yun Lo (2216692), Yu-Ching Huang (815925), Min-Hau Lin (6316361), Yu-Hsin Liao (357463), Yen-Fang Huang (548887), Jyh-Yuan Yang (532172)   +7 more
core   +1 more source

Mental health and family relations among people who inject drugs and their family members in Vietnam. [PDF]

, 2013
BackgroundThis article explores the association of people who inject drugs and their family members in terms of mental health and family relations. The objective was to understand the family context and its impact on people who inject drugs in a family ...
Liang, Li-Jung, Lin, Chunqing, Li, Li, Flore, Martin, Tuan, Nguyen Anh, Farmer, Shu C   +5 more
core   +1 more source

Characteristics of participants at baseline, and 6 months after the intervention, people who inject drugs, Tallinn, Estonia 2018–2019.

, 2023
Characteristics of participants at baseline, and 6 months after the intervention, people who inject drugs, Tallinn, Estonia 2018–2019.
David M. Barnes (798380), Susan Tross (737746), Mait Raag (3713017), Talu Ave (15999162), Don C. Des Jarlais (11726260), Anneli Uusküla (437686)   +5 more
core   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Access to HIV prevention services among people who inject drugs in Dar es Salaam, Tanzania (n = 611).

, 2022
Access to HIV prevention services among people who inject drugs in Dar es Salaam, Tanzania (n = 611).
Mucho M. Mizinduko (6058379), Alexander M. Ishungisa (12015228), Germana H. Leyna (11656027), Melkizedeck T. Leshabari (4419715), Britt P. Tersbøl (12015231), Kåre Moen (5324132), Neema Makyao (5150357), Elia J. Mmbaga (11976405), Dan W. Meyrowitsch (10199121), Samuel L. Likindikoki (12015225), Theis Lange (294658)   +10 more
core   +1 more source

Reported xylazine exposure highly associated with overdose outcomes in a rapid community assessment among people who inject drugs in Baltimore

Harm Reduction Journal
Background Addressing xylazine harms are now a critical harm reduction priority, but relatively little epidemiological information exists to determine prevalence, magnitude, and correlates of xylazine use or related outcomes. Methods We conducted a rapid
Danielle German, Becky Genberg, Olivia Sugarman, Brendon Saloner, Anne Sawyer, Jennifer L. Glick, Molly Gribbin, Colin Flynn   +7 more
doaj   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Multivariable logistic model for oral HPV among 199 people who inject drugs in Baltimore City.

, 2015
Multivariable logistic model for oral HPV among 199 people who inject drugs in Baltimore City.
Weihong Xiao (830121), Maura Gillison (362898), Gypsyamber D’Souza (487538), Yingshi Guo (830122), Shruti H. Mehta (278513), Alicia Wentz (830123), Christina E. Fennell (830120), Gregory D. Kirk (199129), Hilary A. Robbins (830119)   +8 more
core   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source