Results 161 to 170 of about 66,881 (237)

"Trust and suspicion" client and provider perspectives on the acceptability of medication for opioid use disorder among people who inject drugs in Kampala, Uganda. [PDF]

Harm Reduct J
Mudiope P, Nanyeenya N, Okurut S, Twimukye A, Simon K, Mutamba Byamah B, Nangendo J, Alamo S, Makumbi F, Wanyenze R, Matovu JKB.   +10 more
europepmc   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Leveraging injection networks to prevent HIV and other blood borne infections among people who inject drugs in Kenya: design and rationale. [PDF]

BMC Infect Dis
Akiyama MJ, Manley HN, Riback LR, Zhang C, Alvandi A, Gile K, Jiang Y, Nyakowa M, Ganatra N, Bashir I, Colman E, Stone J, Vickerman P, Walker JG.   +13 more
europepmc   +1 more source

Hepatitis C infection in people who inject drugs [PDF]

International Journal of Infectious Diseases, 2016
openaire   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

HIV and syphilis seroprevalence and related unsafe sexual behaviours among people who inject drugs in Georgia: a cross-sectional study. [PDF]

BMJ Open
Kajaia M, Djibuti M, DeHovitz JA, Kamkamidze G, Baliashvili D, Kochlamazashvili M, Kanchelashvili G, Butsashvili M.   +7 more
europepmc   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Characterizing non-fatal overdose among people who inject drugs in India: prevalence and risk factor analysis, 2022-2024. [PDF]

Int J Drug Policy
Gunaratne MP, Loeb TA, McFall AM, Ganapathi L, Baishya JJ, Kedar A, Sinha AK, Srikrishnan AK, Solomon SS, Lucas GM, Mehta SH.   +10 more
europepmc   +1 more source

Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science, EarlyView.
mECs restore blood–brain barrier function after cerebral ischemia–reperfusion by simultaneously targeting, supporting, and regulating the damaged vasculature. mECs home to injured cerebral vessels through interactions with highly expressed VLA‐4, reinforce endothelial integrity by forming new junctions, and, upon OGD‐SN treatment, acquire enhanced ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
wiley   +1 more source

HIV Prevention Among People Who Inject Drugs (PWID): A Narrative Review. [PDF]

Cureus
Matter A, Younan S.
europepmc   +1 more source