Results 161 to 170 of about 69,395 (344)
Redressing the epidemics of opioid overdose and HIV among people who inject drugs in Central Asia: The need for a syndemic approach [PDF]
, 2013 Louisa Gilbert +7 more
openalex +1 more source
Global policy and access to new hepatitis C therapies for people who inject drugs [PDF]
, 2015 Aspinall, Esther +6 more
core +1 more source
Advanced Science, EarlyView.Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li +13 more
wiley +1 more source
Advanced Science, EarlyView.Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser +11 more
wiley +1 more source
Recent and rapid transmission of HIV among people who inject drugs in Scotland revealed through phylogenetic analysis [PDF]
, 2018 Aitken, Celia +9 more
core +2 more sources
Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Punitive policing and associated substance use risks among HIV‐positive people in Russia who inject drugs [PDF]
, 2014 Karsten Lunze +8 more
openalex +1 more source
The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication
Advanced Science, EarlyView.Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li +9 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that circPVT1 promotes the renal cell carcinoma lung metastasis and tumor progression through encoding the cP104aa peptide and directly binds with EIF4A3, which jointly regulates the target gene c‐MYC. Abstract Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC).
Houliang Zhang +10 more
wiley +1 more source
High-risk behaviors after release from incarceration among people who inject drugs in St. Petersburg, Russia [PDF]
, 2014 Javier Cepeda +5 more
openalex +1 more source